en Neurophysiology/Pharmacology Neurophysiology/Pharmacology Review Review <p style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Arial;"><span style="line-height:150%"><span calibri=""><span style="line-height:150%"><span new="" roman="" times="">The newly developed drug delivery systems will make significant progress in the diagnosis and treatment of CNS disorders including autism spectrum disorder. This systematic review was conducted with the aim of elucidating the Molecular Mechanisms of the effect of Nanoparticles on Autism Spectrum Disorder Treatment or Progression. In this investigation, a comprehensive search incorporating pertinent keywords was performed on databases such as PubMed (MEDLINE), Scopus (Elsevier), and the Institute for Scientific Information (ISI) Web of Science, spanning from 1990 to 2023. The predominant findings across most of the research studies indicate an association between exposure to Nanoparticles and the autism spectrum disorder process. Specifically, Nanoparticles like Gold, Bumetanide, Naringenin,</span></span> <span style="line-height:150%"><span new="" roman="" times="">Hesperetin,</span></span> <span style="line-height:150%"><span new="" roman="" times="">Quercetin,</span></span> <span style="line-height:150%"><span new="" roman="" times="">erythropoietin, Zinc Oxide,</span></span> <span style="line-height:150%"><span new="" roman="" times="">Sumac and Gallic acid,</span></span> <span style="line-height:150%"><span new="" roman="" times="">Lutein, and encapsulated Aspirin exhibit therapeutic effects in mitigating autism spectrum disorder. While Titanium dioxide Nanoparticles are implicated in exacerbating the condition. The findings substantiate the link between utilization of/exposure to Nanoparticles and autism spectrum disorder. Moreover, it is worth noting that Nanoparticles, by influencing the oxidative stress, the antioxidant system, immune responses, inflammation, and signaling pathways have been correlated with the manifestation of autism spectrum disorder.</span></span></span></span></span></span></p> nanoparticle,autism spectrum disorder,mechanism,delivery system,drug 0 0 http://ppj.phypha.ir/browse.php?a_code=A-10-2605-1&slc_lang=en&sid=1 Maryam Maleki maryammaleki777@yahoo.com 3200319475328460039962 3200319475328460039962 No Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Maryam Bagheri maryam.bagheri@medilam.ac.ir 3200319475328460039963 3200319475328460039963 No Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Alireza Aliboroni ar81ab@gmail.com 3200319475328460039964 3200319475328460039964 No Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Mohammad Reza Kaffashian kaffashian-mr@medilam.ac.ir 3200319475328460039965 3200319475328460039965 No Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Yousef Veisani veisani-y@medilam.ac.ir 3200319475328460039966 3200319475328460039966 No Non-Communicable Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran maryam kheiry m.kheiry@yahoo.com 3200319475328460039967 0000000322383295 Yes Non-Communicable Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran