Volume 26, Issue 3 (September 2022)
Physiol Pharmacol 2022, 26(3): 288-298 |
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Abstract: (1547 Views)
Introduction: Methamphetamine (METH) addiction is an epidemic-growing problem globally. Studies confirmed a solid linkage between the prefrontal cortex (PFC) and drug seeking. The present study aimed to investigate PFC neural activity changes after injection of METH following METH-induced conditioned place preference (CPP) in the rats.
Methods: After the development of CPP (0.5mg/kg METH for three days, SC), in vivo single-unit recordings were carried out the day after the post-test (post-conditioning day). On recording day, after stabilization and baseline recording (a 10-min period), the injection of METH (0.5mg/kg, SC) was performed and then, PFC neural activity was recorded for a 30-min period.
Results: The results revealed that the injection of METH on the post-conditioning test significantly increases PFC neurons’ firing rate in animals that received METH during the CPP paradigm.
Conclusion: It seems that maybe, PFC neurons appear to be implicated in the associated METH reward pathway and repeated exposure to METH affected the sensitivity of neurons in this area.
Methods: After the development of CPP (0.5mg/kg METH for three days, SC), in vivo single-unit recordings were carried out the day after the post-test (post-conditioning day). On recording day, after stabilization and baseline recording (a 10-min period), the injection of METH (0.5mg/kg, SC) was performed and then, PFC neural activity was recorded for a 30-min period.
Results: The results revealed that the injection of METH on the post-conditioning test significantly increases PFC neurons’ firing rate in animals that received METH during the CPP paradigm.
Conclusion: It seems that maybe, PFC neurons appear to be implicated in the associated METH reward pathway and repeated exposure to METH affected the sensitivity of neurons in this area.
Keywords: Reward system, Prefrontal cortex, Methamphetamine, Neuronal activity, Conditioned place preference
Type of Manuscript: Experimental research article |
Subject:
Blood and Immune System
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