Volume 26, Issue 4 (December 2022)
Physiol Pharmacol 2022, 26(4): 433-439 |
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Okafor I A, Okafor U S. The methanolic extract of Zingiber officinale causes hypoglycemia and proinflammatory response in the rat pancreas. Physiol Pharmacol 2022; 26 (4) :433-439
URL: http://ppj.phypha.ir/article-1-1791-en.html
URL: http://ppj.phypha.ir/article-1-1791-en.html
Abstract: (1383 Views)
Introduction: Zingiber officinale (Ginger) is a commonly used plant for food and herbal treatment of different ailments. There is proof of ginger’s antioxidative and hypoglycemic activity, but the mechanism of action is yet to be understood, especially in a non-disease model. The present study assessed the effects of the methanolic extract of Zingiber officinale (MEZO) on blood glucose, pancreatic antioxidant levels, and histopathological changes. Methods: Fifteen (15) female Wistar rats with an average weight of 147 g were randomly divided into three (3) groups (A-C). Group A was given no treatment and served as the control group. Groups B and C received only oral administration of 400 mg/kg and 800mg/kg of MEZO, respectively. MEZO was administered once a day for 21 days. The animals were euthanized by cervical dislocation for blood collection and retrieval of pancreatic tissue for oxidative stress and histopathological assessment. Results: The serum glucose level was significantly decreased in group C compared to the control (P=0.012). There were no significant changes in the levels of Superoxide dismutase (SOD), Glutathione (GSH), and Catalase (CAT) in all the MEZO groups compared to
the control (P>0.05). Pancreatic histology showed signs of acute pancreatitis, with dense aggregates of polymorphonuclear inflammatory cells infiltrating the surrounding stroma. Conclusion: A high-dose ginger extract induces hypoglycemia, but a proinflammatory response is elicited in the pancreas at a lower dose. Thus, ginger extracts should be consumed with caution.
the control (P>0.05). Pancreatic histology showed signs of acute pancreatitis, with dense aggregates of polymorphonuclear inflammatory cells infiltrating the surrounding stroma. Conclusion: A high-dose ginger extract induces hypoglycemia, but a proinflammatory response is elicited in the pancreas at a lower dose. Thus, ginger extracts should be consumed with caution.
Type of Manuscript: Experimental research article |
Subject:
Endocrine Physiology/Pharmacology
References
1. Abd El-Haleem, M. R., & Mohamed, D. A. (2011). The effects of experimental aflatoxicosis on the pancreas of adult male albino rats and the role of ginger supplementation. The Egyptian Journal of Histology. [DOI:10.1097/ehx.0000398847.67845.55]
2. Abdulrazaq, N. B., Cho, M. M., Win, N. N., Zaman, R., & Rahman, M. T. (2012). Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats. British Journal of Nutrition. [DOI:10.1017/S0007114511006635]
3. Al-Qudah, M. M. A., Haddad, M. A., & El-Qudah, J. M. F. (2016). The effects of aqueous ginger extract on pancreas histology and on blood glucose in normal and alloxan monohydrate-induced diabetic rats. Biomedical Research (India).
4. Arablou, T., Aryaeian, N., Valizadeh, M., Sharifi, F., Hosseini, A., & Djalali, M. (2014). The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. International Journal of Food Sciences and Nutrition. [DOI:10.3109/09637486.2014.880671]
5. Ataman, J. E., & Ojukwu, F. (2014). Protective Effects of Aqueous Extract of Ginger on Castor-oil - Induced Testicular Damage in Wistar Rats. 14(4), 199–205.
6. Committee for the Update of the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Research, Division on Earth and Life Studies, & National Research Council. (2011). Guide for the care and use of laboratory animals (8th ed.). National Academies Press.
7. Guillen J. (2012). FELASA guidelines and recommendations. Journal of the American Association for Laboratory Animal Science : JAALAS, 51(3), 311–321.
8. Habib, S. H. M., Makpol, S., Hamid, N. A. A., Das, S., Ngah, W. Z. W., & Yusof, Y. A. M. (2008). Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats. Clinics. [DOI:10.1590/S1807-59322008000600017]
9. Hosseinzadeh, A., Bahrampour Juybari, K., Fatemi, M. J., Kamarul, T., Bagheri, A., Tekiyehmaroof, N., & Sharifi, A. M. (2017). Protective Effect of Ginger (Zingiber officinale Roscoe) Extract against Oxidative Stress and Mitochondrial Apoptosis Induced by Interleukin-1β in Cultured Chondrocytes. Cells Tissues Organs. [DOI:10.1159/000479789]
10. Imani, A. M., & Ainehchi, N. (2014). Comparison of the Effects of Methotrexate and Ginger Extract on Reproductive Parameters in Rats. 1(3), 103–109.
11. Jafarnejad, S., Keshavarz, S. A., Mahbubi, S., Saremi, S., Arab, A., Abbasi, S., & Djafarian, K. (2017). Effect of ginger (Zingiber officinale) on blood glucose and lipid concentrations in diabetic and hyperlipidemic subjects: A meta-analysis of randomized controlled trials. In Journal of Functional Foods. [DOI:10.1016/j.jff.2016.12.006]
12. Jean-Marie, E. (2018). Diagnosis and classification of diabetes mellitus. In Encyclopedia of Endocrine Diseases. [DOI:10.1016/B978-0-12-801238-3.65822-1]
13. Jolad, S. D., Lantz, R. C., Solyom, A. M., Chen, G. J., Bates, R. B., & Timmermann, B. N. (2004). Fresh organically grown ginger (Zingiber officinale): Composition and effects on LPS-induced PGE2 production. Phytochemistry, 65(13), 1937–1954. [DOI:10.1016/j.phytochem.2004.06.008]
14. Khansari, N., Shakiba, Y., & Mahmoudi, M. (2009). Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer . Chronic Inflammation and Oxidative Stress as a Major Cause of Age-Related Diseases and Cancer. June 2015. [DOI:10.2174/187221309787158371]
15. Kilkenny, C., Browne, W., Cuthill, I. C., Emerson, M., Altman, D. G., & NC3Rs Reporting Guidelines Working Group (2010). Animal research: reporting in vivo experiments: the ARRIVE guidelines. British journal of pharmacology, 160(7), 1577–1579. [DOI:10.1111/j.1476-5381.2010.00872.x]
16. Lantz, R. C., Chen, G. J., Sarihan, M., Sólyom, A. M., Jolad, S. D., & Timmermann, B. N. (2007). The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine. [DOI:10.1016/j.phymed.2006.03.003]
17. Mahluji, S., Attari, V. E., Mobasseri, M., Payahoo, L., Ostadrahimi, A., & Golzari, S. E. (2013). Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. International Journal of Food Sciences and Nutrition. [DOI:10.3109/09637486.2013.775223]
18. Mashhadi, N. S., Ghiasvand, R., Askari, G., Hariri, M., Darvishi, L., & Mofid, M. R. (2013). Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: Review of current evidence. In International Journal of Preventive Medicine.
19. Mbaveng, A. T., & Kuete, V. (2017). Zingiber officinale. In Medicinal Spices and Vegetables from Africa: Therapeutic Potential Against Metabolic, Inflammatory, Infectious and Systemic Diseases. [DOI:10.1016/B978-0-12-809286-6.00030-3]
20. McGuckin, E., Cade, J. E., & Hanison, J. (2020). The pancreas. In Anaesthesia and Intensive Care Medicine. [DOI:10.1016/j.mpaic.2020.08.005]
21. Minaiyan, A, G., & A, K. (2006). Anti-ulcerogenic effect of ginger (rhizome of Zingiber officinale Roscoe) on cysteamine induced duodenal ulcer in rats. Daru.
22. Okafor, I. A., Ayalokunrin, M. B., & Orachu, L. A. (2014). A review on Portulaca oleracea (Purslane) plant Its nature and biomedical benefits. International Journal of Biomedical Research, 5(2), 75–80. [DOI:10.7439/ijbr.v5i2.462]
23. Okafor, I. A., & Gbotolorun, S. C. (2018). Resveratrol prevents cisplatin-induced lipid peroxidation in the non-gravid uterus of Sprague-Dawley rats. Middle East Fertility Society Journal. [DOI:10.1016/j.mefs.2017.12.003]
24. Okafor, I. A., Nnamah, U. S., Nweke, J. O., Nnaka, J. A., Ahiatrogah S., & Okeke, U. V. (2020a). Zingiber officinale (Ginger) extract has no effect on Kiss1 gene expression in the testis and blood but may cause inflammation-induced morphological sperm disruptions in Wistar rats. Acta Scientific Medical Sciences Volume 4 Issue 12: 17-25. DOI: [DOI:10.31080/ASMS.2020.04.0789]
25. Okafor, I. A., Nnamah, U. S., Nweke, J. O., Nnaka, J. A., Ahiatrogah S., Okeke, U. V., & Okoro, C. C. (2020b). The Role of Zingiber officinale (Ginger) Extract in the Kiss1 Gene Expression in the Ovary and Blood of Wistar Rats. Acta Scientific Medical Sciences Volume 4 Issue 11: 89-96. DOI: [DOI:10.31080/ASMS.2020.04.0777]
26. Shahrajaban, M. H., Sun, W., & Cheng, Q. (2019). Pharmacological Uses and Health Benefits of Ginger (Zingiber officinale) in Traditional Asian and Ancient Chinese Medicine, and Modern Practice. Notulae Scientia Biologicae. [DOI:10.15835/nsb11310419]
27. Sharma, A., Flores-Vallejo, R. del C., Cardoso-Taketa, A., & Villarreal, M. L. (2017). Antibacterial activities of medicinal plants used in Mexican traditional medicine. In Journal of Ethnopharmacology. [DOI:10.1016/j.jep.2016.04.045]
28. Shukla, Y., & Singh, M. (2007). Cancer preventive properties of ginger: A brief review. In Food and Chemical Toxicology. [DOI:10.1016/j.fct.2006.11.002]
29. Tripathi, P., Gupta, G., & Chauhan, P. S. (2018). Role of Phytomedicine in Diabetes and Cardiovascular Diseases. In New Look to Phytomedicine: Advancements in Herbal Products as Novel Drug Leads. [DOI:10.1016/B978-0-12-814619-4.00017-3]
30. Yeh, H. yu, Chuang, C. hung, Chen, H. Chun, Wan, C. Jen, Chen, T. Liang, & Lin, L. Yun. (2014). Bioactive components analysis of two various gingers (Zingiber officinale Roscoe) and antioxidant effect of ginger extracts. LWT - Food Science and Technology. [DOI:10.1016/j.lwt.2013.08.003]
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