Volume 17, Issue 2 (Summer 2013)                   Physiol Pharmacol 2013, 17(2): 224-230 | Back to browse issues page

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Noori-Ahmadabadi M, Hojjati M R, Sedighi hafshejani M. Effect of hydro-alcoholic extract of Ziziphus Jujuba on the peripheral blood cells in Balb/c mice. Physiol Pharmacol 2013; 17 (2) :224-230
URL: http://ppj.phypha.ir/article-1-901-en.html
Effect of hydro-alcoholic extract of Ziziphus Jujuba on the peripheral blood cells in Balb/c mice
Mosayeb Noori-Ahmadabadi , Mohammad reza Hojjati , Mehrnoosh Sedighi hafshejani
Abstract:   (9611 Views)
Introduction: In the Iranian traditional medicine, Ziziphus jujuba is recommended for treatment of anemia, but no investigation has addressed this issue. In the present study, the effect of hydro-alcoholic extract of this plant was evaluated on the peripheral blood cells in male Balb/c mice. Methods: Hydro-alcoholic extract was prepared from the fruits of the Ziziphus jujuba. Male mice were injected with normal saline or the extract (100, 200 or 400 mg/kg, i.p.) for a period of two weeks. Afterwards, the mice were anesthetized and blood samples were taken from their hearts and then the peripheral blood was evaluated by a Cell Counter apparatus. White blood cells differential analysis was manually performed under a microscope. Data was statistically analyzed using One-way ANOVA followed by Tukey post-hoc test. Results: Ziziphus jujuba extracts (100 and 400 mg/kg) caused a significant reduction in the percentages of monocytes and neutrophils, respectively (P<0.05). At a dose of 400 mg/kg, Ziziphus jujuba extract increased the percentage of lymphocytes (P<0.05). However, no significant changes were observed in the amounts of WBC, RBC, platelets, hemoglobin, Hct, MCV, MCH and MCHC in the extract-treated groups (P>0.05). Conclusion: Findings of this study show that Ziziphus jujuba extract increases the percentage of lymphocytes and also reduces the percentage of monocytes and neutrophils.
Keywords: Ziziphus jujuba, Extract, Peripheral blood cells, Mice
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Type of Manuscript: Experimental research article | Subject: Blood and Immune System
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