Gholampour F, Owji S M, Mousavinia S S. Berberine Ameliorates Renal Functional Disorders and Pulmonary Tissue Injury Following Renal Ischemia/Reperfusion in Rats. Physiol Pharmacol 2014; 18 (1) :82-91
URL:
http://ppj.phypha.ir/article-1-992-en.html
Abstract: (9206 Views)
Introduction: This study investigated the effect of berberine on renal dysfunction and histological damages of the
lung induced by renal ischemia/ reperfusion at an early stage.
Methods: There were four experimental groups of adult male rats (n=7). Seven days before induction of ischemia,
the Ber+I/R group received oral (by gavage) berberine (15 mg/kg/day) while the I/R group received distilled water.
Renal arteries were not occluded in the sham group and Ber+sham group, and they were administered distilled water
and berberine (15 mg/kg/day), respectively, by gavage 7 days before surgery. Renal ischemia was induced by occlusion
of both renal arteries for 45 min followed by 24 h of reperfusion. Blood samples were collected for biochemical
analysis, and finally lung samples were preserved for light microscopical examination.
Results: The 45 min ischemia/24 h reperfusion resulted in renal functional disorders and histological damages to the
lung, which were associated with increased plasma levels of creatinine, blood urea nitrogen (BUN), lactate
dehydrogenase (LDH) and alkaline phosphatase (ALK) during reperfusion period. In the Ber+I/R group, renal
functional disorders and histological damage to the lung were improved, which was accompanied by less increase in
plasma creatinine, BUN, LDH and ALK than those of the non-treated rats.
Conclusion: Berberine has an ameliorative effect on renal as well as pulmonary injuries following renal
ischemia/reperfusion in rats.