%0 Journal Article %A Hoseinzadeh, Mahshid %A Pouraboli, Iran %A Abbasnejad, Mehdi %A Pouraboli, Batool %T Effect of coadministeration of NO and morphine in CA3 of hippocampus on learning and spatial memory in morphine dependent male rats %J Physiology and Pharmacology %V 11 %N 4 %U http://ppj.phypha.ir/article-1-239-en.html %R %D 2008 %K Keywords:Learning, SpatialMemory, Morphinedependency, Hippocampus, NO, %X Abstract: ِIntroduction: The effect of morphine dependency on learning and spatial memory is controversial. So in this study effect of co-administeration of nitric oxide (NO) and morphine in CA3 of hippocampus on learning and spatial memory in morphine dependent rats was investigated. Methods: After anaesthetization of male rats, cannulae implanted bilaterally in CA3 of hippocampus. After recovery period (7 days), morphine dependency induced then animals divided in 6 groups that received 1μl saline (Sham), L-Arginine, L-Name and morphine individually and L-Arginine with morphine or L-Name with morphine individually. Morphine dependency was induced by subcutaneous injection of morphine(10mg/kg first day and 20mg/kg for four days). Last dose of morphine(20mg/kg) was injected daily to maintain morphine dependency during test period (5 days) in morris water maze Results: Results showed that L-Name decreased learning in morphine dependent rats although was ineffective on retention of memory. Morphine did not affect learning and spatial memory. Co-administeration of L-Arginine and morphine not only improved the effect of morphine on learning and memory but also promote the effect of L-Arginine on learning and spatial memory. Conclusion: Thus co-administeration of NO and morphine in morphine dependent rats can improve learning and spatial memory differently from using them individually. %> http://ppj.phypha.ir/article-1-239-en.pdf %P 293-299 %& 293 %! %9 Experimental research article %L A-10-102-2 %+ %G eng %@ 24765236 %[ 2008