TY - JOUR T1 - The role of histamine receptors in restraint stress-induced immunosuppression in the rat brain TT - نقش گیرنده های مرکزی هیستامین در مهار فعالیت سیستم ایمنی به دنبال استرس بی حرکتی (restraint) در موش صحرایی JF - Physiol-Pharmacol JO - Physiol-Pharmacol VL - 4 IS - 1 UR - http://ppj.phypha.ir/article-1-235-en.html Y1 - 2000 SP - 39 EP - 48 KW - Restraint stress; Histamine; Immune system; Central histamine receptors N2 - Restraint-induced stress (RS) increases histamine concentration in the brain. There is no previous report regarding the role of histamine receptors in immunomodulatory effect of RS. In the present study the role of brain histamine receptors on reduction of humoral and cellular immune function induced by RS was evaluated. For this purpose male Wistar rats (200-250 g) were immunized with sheep red blood cells (SRBCs). The results showed that RS reduced the humoral and cell-mediated immunity in immunized rats (p M3 ER -