RT - Journal Article T1 - The effect of CCK receptor agonists and antagonists in sciatic nerve-ligated mice JF - Physiol-Pharmacol YR - 1998 JO - Physiol-Pharmacol VO - 2 IS - 2 UR - http://ppj.phypha.ir/article-1-334-en.html SP - 128 EP - 136 K1 - Nerve ligation; Morphine; CCK receptor agents AB - The effects of caerulin, a CCK receptor agonist, and proglumide, a receptor antagonist, on hyperalgesia induced by sciatic nerve ligation, was studied in mice. Tolerance to the morphine response was obtained 3,7, 14,21 and 28 days after unilateral sciatic nerve ligation. Maximum hyperalgesia was found 14 days after nerve ligation. Caerulin increased morphine antinociception in nerve-ligated animals. The drug also induced antinociception in intact animals. Proglumide also induced antinociception in nerve-ligated mice. The antagonist increased the morphine response but did not alter the effect of caerulin. We conclude that the CCK receptor mechanism may have a role in hyperalgesia induced by nerve ligation LA eng UL http://ppj.phypha.ir/article-1-334-en.html M3 ER -