@ARTICLE{GharibNaseri, author = {GharibNaseri, MohammadKazem and Zarepoor, Leila and Mojab, Samad and }, title = {Effect of flavonoid quercetin on stress-induced gastric ulcer in rats}, volume = {11}, number = {1}, abstract ={Introduction: Mental stress is one of the most important causes of the gastric ulcer. On the other hand, flavonoids such as quercetin show protective effects. The aim of this study was to investigate possible protective effect of quercetin on water restraint stress-induced ulcer in rats. Methods: Adult male Wistar rats were divided into seven groups each containing eight animals. The first group (S) received normal saline (5 ml/kg, p.o.) and groups 2-7 received normal saline, quercetin 25, 50, 100, 200 (mg/kg, p.o.) or omeprazole (20 mg/kg, s.c.) respectively. After 1 hour, all animals except the first group (S) were placed into the plexiglass restrainers and kept in water (23°C) for 3.5 hours. After another 3.5 hours interval, rats were scarified and volume of gastric output, pH, acid content and ulcer index (UI) were measured. Results: pH of gastric content in QS50-QS200 groups was lower than the saline/stress (SS) treated group (P }, URL = {http://ppj.phypha.ir/article-1-373-en.html}, eprint = {http://ppj.phypha.ir/article-1-373-en.pdf}, journal = {Physiology and Pharmacology}, doi = {}, year = {2007} }