%0 Journal Article %A Hallak, Mohamad %A Balci, Hakan %A Günaydın, Caner %A Bilge, S. Sirri %T The role of muscarinic and serotonergic-2A receptors in the antinociceptive effect of pregabalin %J Physiology and Pharmacology %V 23 %N 4 %U http://ppj.phypha.ir/article-1-1473-en.html %R %D 2019 %K Pregabalin, Somatic pain, Ketanserin, Atropine., %X Introduction: Pregabalin (PGB) is an analog of gamma-aminobutyric acid (GABA) with antinociceptive, antihyperalgesic and antiallodynic properties which frequently used in clinical pain management. Effect of PBG in neuropathic pain, incisional-inflammatory injury, post-operational pain, chronic pain and experimental pain models have already shown. It has been already known that muscarinic and serotonergic-2A receptors have a role in pain transmission. Methods: in this study, role of muscarinic and serotonergic-2A receptors in antinociceptive effect of pregabalin were evaluated with hot-plate and tail flick tests and effects of administered drugs on locomotor activity were measured with automated activity cage. Results: PGB treatment (30 and 100mg/kg) caused longer latency in hot plate and tail flick tests than saline group. That antinociceptive effect of pregabalin abolished by ketanserin (1mg/kg) and atropine (1mg/kg) treatment. Conclusion: However, there is lack of knowledge about role of nociceptive pathways underlying pregabalin mediated antinociception. Our results suggest that cholinergic and serotonergic systems have a role in antinociceptive effect of PGB which has seen in these somatic pain tests. %> http://ppj.phypha.ir/article-1-1473-en.pdf %P 302-308 %& 302 %! Pregabalin antinociceptive action %9 Experimental research article %L A-10-1207-1 %+ Ondokuz Mayıs University, School of Medicine, Deparment of Pharmacology 55139, Atakum, Samsun, Turkey %G eng %@ 24765236 %[ 2019