TY - JOUR T1 - The effect of intragastric D-glucose on hyperacidity induced by histamine and carbachol in male rat TT - بررسی اثر D - گلوکز داخل معدی بر هایپراسیدیتی ناشی از هیستامین و کرباکول در موش صحرایی نر JF - Physiol-Pharmacol JO - Physiol-Pharmacol VL - 5 IS - 1 UR - http://ppj.phypha.ir/article-1-127-en.html Y1 - 2001 SP - 35 EP - 41 KW - lntragastric D-glucose; Carbachol; Histamine; Gastric acid N2 - It has been shown that enhanced acid secretion can be suppressed in the rat by systemic administration of glucose. We have recently reported that enhancement of acid secretion as a result of pentagastrin was diminished by intragastric administration of D-glucose. Present study was designed to investigate whether intragastric D-glucose influences gastric acid secretion associated with carbachol and histamine in rat, and then we compared these results with our previous results obtained by pentagastrin-induced hyperacidity. Intravenous infusion of carbachol (1 mg/100 g/h) and histamine (0.5 mg/100 g/h) caused an immediate increase in acid secretion with a peak starting after 40 and 60 min and then reached to a steady state respectively. 1ntragastric administration of D-glucose significantly reduced the hyperacidity induced by histamine and carbachol (p M3 ER -