%0 Journal Article %A Sha'abani, Sanaz %A Gazerani, Sasan %A Ragheb, Maryam %A Mirgalou-Bayat, Amir-Hossein %A Huntington, Mark Kennet %T Effect of minocycline on lumbar radicular pain: a prospective pilot study %J Physiology and Pharmacology %V 24 %N 3 %U http://ppj.phypha.ir/article-1-1572-en.html %R 10.32598/ppj.24.3.50 %D 2020 %K Minocycline, Low back radicular pain, Chronic pain., %X Introduction: Pain is an unpleasant sensory and emotional experience. Evidence suggests a role for microglia in chronic pain and inhibition of microglia leads to decrease of chronic pain intensity in animal models. Minocycline, a semisynthetic tetracycline derivative, is a selective inhibitor of microglia. Several studies have shown pain intensity improvement by minocycline in animal model of pain, but a few studies showed effectiveness on chronic pain improvement in humans. This prospective, self-controlled clinical trial investigated whether minocycline is effective for chronic pain management. Methods: Twenty-two patients, between the ages of 20 and 80 years with radicular lumbar pain with a numerical rating scale >4, who were unresponsive to other medications and had pain duration of >6 weeks were included in the trial. Results: Pain intensity, neuropathic pain and life quality scores assessed before and after treatment. All scores showed significant improvement after 2 weeks of treatment: 56%, 74% and 14%, respectively. Conclusion: Findings of this study suggest minocycline can effectively improve patients’ pain scores and quality of life, even in those with long-term duration of chronic pain and warrants further study. %> http://ppj.phypha.ir/article-1-1572-en.pdf %P 197-201 %& 197 %! Minocycline and chronic pain %9 Experimental research article %L A-10-1320-1 %+ Department of Physiology, Saveh University of Medical Sciences, Saveh,, Iran %G eng %@ 24765236 %[ 2020