TY - JOUR JF - Physiol-Pharmacol JO - Physiol Pharmacol VL - 14 IS - 4 PY - 2011 Y1 - 2011/1/01 TI - Comparison between the effects of L-Carnitine and Acetyl-L-Carnitine on myocardial infarction size in ischemic heart TT - N2 - Introduction: In the present study, potential differences between the effects of L-carnitine (LC) and acetyl-Lcarnitine (ALC) on ischemia/reperfusion (I/R)-induced myocardial infarction size were investigated. Methods: Male Wistar rats were randomly divided into five groups and then anesthetized by sodium pentobarbital. Hearts of the animals were removed and quickly mounted on a Langendorff apparatus and perfused under constant pressure by a modified Krebs-Henseleit (K/H) solution. The hearts were perfused during 30 min regional ischemia followed by 120 min reperfusion by normal K/H solution (as control) or enriched solution with 1.5 and 3 mM LC (groups 2 and 3) or ALC (groups 4 and 5). At the end of the reperfusion cycle, 0.25 % evans blue solution was infused to stain the non-ischemic area, then the hearts were cut into slices and incubated by triphenyltetrazolium chloride solution and fixed by formalin. The infarction size was determined by using a computerized planimetry package. Results: The infarct size after perfusion of isolated hearts with 1.5 (26±4.5%) and 3 mM LC (20±4 %) showed a significant reduction compared to the control value (45.6±3.4 %, P SP - 380 EP - 388 AU - Najafi, Moslem AU - Ghaffary, Saba AU - Shaseb, Elnaz AU - Eteraf Oskouei, Tahereh AD - School of Pharmacy KW - L-carnitine KW - Acetyl-L-carnitine KW - Infarction size KW - Isolated heart KW - Rat UR - http://ppj.phypha.ir/article-1-643-en.html ER -