AU - Fereidoni, Masoud AU - Javan, Mohammad AU - Semnanian, Saeed AU - Ahmadiani, Abolhasan TI - Hypothalamus Pituitary Adrenal axis and stimulatory G proteins signaling role in nociceptive changes induced by forced swim stress PT - JOURNAL ARTICLE TA - Physiol-Pharmacol JN - Physiol-Pharmacol VO - 10 VI - 4 IP - 4 4099 - http://ppj.phypha.ir/article-1-288-en.html 4100 - http://ppj.phypha.ir/article-1-288-en.pdf SO - Physiol-Pharmacol 4 AB  - Introduction: Different mechanisms are involved in stress induced analgesia (SIA) and hyperalgesia (SIH). Repeated stress induces development of tolerance to SIA. The role of HPA axis and Gs signaling pathway in these effects are investigated in the current study. Methods: Forced swim stress (5 min/day) in water (20±1 ºC) was employed to adult male Wistar rats (200-250 g). The nociceptive threshold was assessed using tail flick test. Adrenalectomized (ADX) rats were also subjected to stress tests. Oseltamivir was used to block Gs signaling pathway. Results: Stress produced analgesia for 1 h (p CP - IRAN IN - Dept. Physiology, School of Medical Sciences, Tarbiat Modares University. Tehran, Iran. LG - eng PB - Physiol-Pharmacol PG - 291 PT - Experimental research article YR - 2007