TY - JOUR JF - Physiol-Pharmacol JO - Physiol Pharmacol VL - 13 IS - 4 PY - 2010 Y1 - 2010/1/01 TI - Study of the correlation between ACE gene polymorphism and coronary artery disease TT - ارتباط بین پلی مورفیسم ژن آنزیم مبدل آنژیوتانسین (ACE) و بیماری عروق کرونر N2 - Introduction: Angiotensin converting enzyme (ACE) is an exopeptidase that converts Angiotensin I to Angiotensin II. Angiotensin II is a potent vasoconstrictor and releases aldosterone, and have a critical role in hypertension. In this study, ACE insertion / deletion (I/D) polymorphism and ACE activity was determined in patients with coronary artery disease (CAD) and normal subjects. The correlation of these parameters with important CAD risk factors were also evaluated. Methods: 204 subjects were assigned to patients and normal groups based on their angiography results. Serum ACE activities were assayed by HPLC and I/D polymorphism were analyzed by PCR method. Important risk factors such as diabetes mellitus, hypertension, lipid profiles, ejection fraction, smoking and opium consumption were also recorded. Results: CAD was higher in DD genotype subjects (OR= 2.45 CI= 1.05-5.73), and ACE activity was about twice in DD compared to II genotypes. ACE activity was higher in hypertensives and diabetics in CAD group (p SP - 362 EP - 370 AU - Saadat, Habibolah AU - Ziai, Seyed ali AU - Nasri, Sima AU - Sakenshaft, Mina AU - Ansarian, Atefe AD - KW - Angiotensin converting enzyme KW - Coronary artery disease KW - CAD KW - Insertion / deletion polymorphism. UR - http://ppj.phypha.ir/article-1-570-en.html ER -