en Nervous system (others) Others Experimental research article Experimental research article Introduction: Considering the antiepileptogenic effects of repeated transcranial magnetic stimulation (rTMS), the effect of rTMS applied during amygdala kindling on spontaneous activity of hippocampal CA1 pyramidal neurons was investigated. Materials and Methods: A tripolar electrode was inserted in basolateral amygdala of Male Wistar rats. After a recovery period, animals received daily kindling stimulations until they reached stage 5 seizure. In one group of animals, rTMS at frequency of 1 Hz were applied to hippocampus once daily at 5 min after termination of kindling stimulations. 24 h after the last kindling stimulation, spontaneous activity of CA1 pyramidal neurons of the hippocampus was investigated using whole cell patch clamp technique. Results: Kindling-induced seizures resulted in increment of spontaneous activity of hippocampal CA1 neurons, but application of rTMS during amygdala kindling prevented it. Moreover, rTMS administration inhibited the kindling-induced enhancement of afterdepolarization (ADP) amplitude and action potential duration. Conclusion: Results of this study suggest that rTMS exerts its anticonvulsant effect, in part, through preventing the amygdala kindling-induced increase in spontaneous activity and excitability of hippocampal CA1 pyramidal neurons. Epilepsy, kindling, Transcranial magnetic stimulation, Action potentials 1 13 http://ppj.phypha.ir/browse.php?a_code=A-10-51-14&slc_lang=en&sid=1 Amir Shojaei amshojaei@hotmail.com 3200319475328460015005 3200319475328460015005 No Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Saeed Semnanian ssemnan@modares.ac.ir 3200319475328460015006 3200319475328460015006 No Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Mahyar Janahmadi mjanahmadi@yahoo.com 3200319475328460015007 3200319475328460015007 No Department of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Homeira Moradi homayra_moradi@yahoo.com 3200319475328460015008 3200319475328460015008 No Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Seyad Mohammad Firoozabadi pourmir@modares.ac.ir 3200319475328460015009 3200319475328460015009 No Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Javad Mirnajafi-Zadeh mirnajaf@modares.ac.ir 3200319475328460015010 3200319475328460015010 Yes Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran