Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1394
9
1
gregorian
2015
12
1
19
4
online
1
fulltext
en
Dissimilar mechanistic background of peripheral and orofacial hyperkinesia in patients with Parkinson’s disease and levodopa-induced dyskinesia
Neurophysiology/Pharmacology
Neurophysiology/Pharmacology
Experimental research article
Experimental research article
<p dir="ltr" style="text-align: justify;"><span style="font-size:11px;">Introduction: Long-term levodopa treatment of Parkinson’s disease (PD) is frequently complicated by spontaneously occurring involuntary muscle movements called dyskinesia. The exact pathological mechanism of this complication has not yet been elucidated. We have previously demonstrated that in PD patients the vulnerability to develop peripheral but not orofacial dyskinesia is associated with the presence of two variants of the GRIN2A gene. Moreover, we have shown that in tardive dyskinesia (TD) orofacial dyskinesia is associated with other polymorphisms as compared with peripheral dyskinesia. In the present study we investigate whether the peripheral versus orofacial nature of levodopa-induced dyskinesia (LID) in PD can be explained by considering polymorphisms for dopaminergic and serotonergic receptors. Materials and Methods: 101 Russian patients with PD (38M/63F) were examined. Genotyping was carried out on 19 SNPs for 3 neurotransmitter genes: 10 SNPs for DRD3 gene (rs11721264, rs167770, rs3773678, rs963468, rs7633291, rs2134655, rs9817063, rs324035, rs1800828, rs167771), 1 SNP for DRD4 gene (rs3758653), and 8 SNPs for HTR2C gene (rs6318, rs5946189, rs569959, rs17326429, rs4911871, rs3813929, rs1801412, rs12858300). Results: Genotyping patients with PD and LID revealed that only rs3773678 (DRD3, dominant, p = 0.042) was associated with orofacial dyskinesia. Conclusion: The findings of the current study are not related to LID in PD itself, but to other forms of orofacial dyskinesia in this patient group.</span></p>
Levodopa-induced dyskinesia, Parkinson’s disease, Dopaminergic receptors, Serotonergic receptors, Genetic variants
216
221
http://ppj.phypha.ir/browse.php?a_code=A-10-891-1&slc_lang=en&sid=1
Svetlana A
Ivanova
svetlana@mail.tomsknet.ru
3200319475328460015821
3200319475328460015821
No
Mental Health Research Institute, Tomsk, Russian Federation
Olga Yu
Fedorenko
f_o_y@mail.ru
3200319475328460015822
3200319475328460015822
No
Mental Health Research Institute, Tomsk, Russian Federation
Maxim B
Freidin
mfreidin@medgenetics.ru
3200319475328460015823
3200319475328460015823
No
Research Institute for Medical Genetics, Tomsk, Russian Federation
Valentina M
Alifirova
alifirova@mail2000.ru
3200319475328460015824
3200319475328460015824
No
Department of Neurology and Neurosurgery, Siberian State Medical University, Tomsk, Russian Federation
Natalia G
Zhukova
znatali@yandex.ru
3200319475328460015825
3200319475328460015825
No
Department of Neurology and Neurosurgery, Siberian State Medical University, Tomsk, Russian Federation
Irina A
Zhukova
irzhukova@inbox.ru
3200319475328460015826
3200319475328460015826
No
Department of Neurology and Neurosurgery, Siberian State Medical University, Tomsk, Russian Federation
Asmar FY
Al Hadithy
a.alhadithy@parnassiabavogroep.nl
3200319475328460015827
3200319475328460015827
No
Department of Pharmacotherapy and Pharmaceutical Care, University of Groningen, Groningen, The Netherlands
Jacobus RBJ
Brouwers
jrbjbrouwers@live.nl
3200319475328460015828
3200319475328460015828
No
Department of Pharmacotherapy and Pharmaceutical Care, University of Groningen, Groningen, The Netherlands
Nikolay A
Bokhan
nikolay.bokhan.tomsk.russia@gmail.com
3200319475328460015829
3200319475328460015829
No
Mental Health Research Institute, Tomsk, Russian Federation
Bob
Wilffert
b.wilffert@rug.nl
3200319475328460015830
3200319475328460015830
No
Department of Pharmacotherapy and Pharmaceutical Care, University of Groningen, Groningen, The Netherlands
Anton JM
Loonen
a.j.m.loonen@rug.nl
3200319475328460015831
3200319475328460015831
Yes
Department of Pharmacotherapy and Pharmaceutical Care, University of Groningen, Groningen, The Netherlands