en Cell, Stem Cell and Cancer Cell, Stem Cell and Cancer Letter to the editor Letter to the editor <p dir="ltr" style="margin: 0in 0in 0pt; line-height: 200%; text-align: justify;"><span style="font-size:12px;">Amniotic epithelial cells (AECs) possess unique characteristics, which make them a suitable source for cell-based therapeutic strategies. AECs have stem cell properties with low-immunogenicity (due to expressing HLA-G molecule and absence of MHC class I and II antigens) and no ethical problems, as well as availability in sufficient numbers, which can be obtained from a placenta. We have recently shown that the AECs have anti-cancer properties due to inhibition of angiogenesis, induction of apoptosis and cell cycle arrest probably through inhibition of HSP90. Since the viability of AECs must be improved after in vivo administration in acidic microenvironment of tumor, we clarify here that low pH preconditioning of AECs would lead to more survival of implanted cells in tumor site as well as improved functional outcomes.</span></p> Amniotic membrane, Epithelial cells, Preconditioning, Cancer, Stem cell therapy. 1 4 http://ppj.phypha.ir/browse.php?a_code=A-12-666-3&slc_lang=en&sid=1 Hassan Niknejad niknejad@sbmu.ac.ir 3200319475328460016162 3200319475328460016162 Yes Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ghasem Yazdanpanah gh.yazdnpnha69@gmail.com 3200319475328460016163 3200319475328460016163 No Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mona Kakavand mkaka5426954@yahoo.com 3200319475328460016164 3200319475328460016164 No Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Yasaman Lavaie Yasaman_jasmine54215@yahoo.com 3200319475328460016165 3200319475328460016165 No Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran