en Pharmacokinetics/Dynamics Pharmacokinetics/Dynamics Experimental research article Experimental research article <p dir="ltr"><span style="font-size:12px;">Introduction: The aim of the study was to investigate the effects of Curcuma longa (C. longa) extract on Adriamycin-induced hepatotoxicity in rat.<br /> Methods: Animals were divided in six groups: Control (CO), Adriamycin (ADR), Adriamycin with Vitamin C (ADR+VitC), Vitamin C (Vit C), C. longa with Adriamycin (CL+ADR) and without Adriamycin (CL-ADR). Hepatotoxicity was induced by Adriamycin 5mg/kg and rats were treated with C. longa 1000 mg/kg and Vitamin C 100 mg/kg , per day, orally for 4 weeks.<br /> Results: In the liver tissue of ADR group, Malonyldialdehyde (MDA) level was increased significantly compared to CO group, (p < 0.05). MDA level in the treatment groups, Vit C, CL+ADR and CL-ADR were increased significantly compared to ADR group (p < 0.05, for all three groups), and compared to ADR+VitC group (p < 0.01). Thiol level in ADR, ADR+VitC and CL+ADR groups were decreased compared to CO group (p < 0.001), and also thiol level in CL-ADR and Vit C were increased significantly compared to ADR group (p < 0.01 and p < 0.001 respectively). The activity of catalase in liver tissue in ADR group was lower compared to CO group (p < 0.01), though was increased in CL-ADR, ADR+VitC and Vit C groups in comparison with ADR group (p<0.05, p < 0.01 and p < 0.001, respectively).<br /> Conclusion: The results showed that chronic administration of C. longa hydroalcoholic extract in Adriamycin-induced hepatotoxic rats could decrease the oxidative stress injuries in the liver tissue.</span></p> Adriamycin, Curcuma longa, Hepatotoxicity, Oxidative stress, Hydroalcoholic extract, Rat 31 37 http://ppj.phypha.ir/browse.php?a_code=A-10-897-1&slc_lang=en&sid=1 Mohammad Reza Khazdair khazdeirr921@mums.ac.ir 3200319475328460016173 3200319475328460016173 No Pharmaceutical Research Center and Department of Physiology School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Reza Mohebbati mohebbatir931@mums.ac.ir 3200319475328460016174 3200319475328460016174 Yes Department of Physiology, School of Medicine, Medical University of Mashhad, Mashhad, Iran Sareh Karimi KarimiS911@mums.ac.ir 3200319475328460016175 3200319475328460016175 No Department of Physiology, School of Medicine, Medical University of Mashhad, Mashhad, Iran Abbasali Abbasnezhad abbasnezhad.abbasali@gmail.com 3200319475328460016176 3200319475328460016176 No Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran Milad Haghshenas 3200319475328460016177 3200319475328460016177 No Department of Physiology, School of Medicine, Medical University of Mashhad, Mashhad, Iran