en Pharmacokinetics/Dynamics Pharmacokinetics/Dynamics Experimental research article Experimental research article <p dir="ltr" style="text-align: justify;"></p> <p dir="ltr" style="text-align: justify;"><span style="font-size: 12px;"><b>Introduction: </b><font face="Arial,Arial"><font face="Arial,Arial">For thousands of years, plants have been used as the main source of drug worldwide. Recently, it has been found out that the plant Artemisia annua and especially its derivatives such as artemether have anticancer properties. </font></font></span><span style="font-size: 12px;"><b>Methods: </b><font face="Arial,Arial"><font face="Arial,Arial">In this study, the anticancer effect of artemether on MCF-7 breast cancer cell line was examined. MTT assay was used to assess the viability of cancer cells. </font></font></span><span style="font-size: 12px;"><b>Results: </b><font face="Arial,Arial"><font face="Arial,Arial">The data showed that artemether (100-300 nM) resulted in MCF-7 growth inhibition. Artemether plus vincristine or doxorubicin compared to each drug alone showed significant cytotoxic effects. Over 50 percent of cells were killed in combination of non-effective doses of artemether and doxorubicin (50 and 160 nM, respectively). </font></font></span><span style="font-size: 12px;"><b>Conclusion: </b><font face="Arial,Arial"><font face="Arial,Arial">Taken together, the combined therapy of artemether and anticancer drugs would be a promising strategy for breast cancer but the effectiveness of such combination therapy needs to be verified by experimental and clinical investigations. </font></font></span></p> Breast cancer cell line, MCF-7, Artemether, Cell viability, Chemotherapy 117 121 http://ppj.phypha.ir/browse.php?a_code=A-10-79-8&slc_lang=en&sid=1 Mohammad Rasoul Samandari-Bahraseman m.r.samandari@gmail.com 3200319475328460016426 3200319475328460016426 No Research Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, GraduateUniversity of Advanced Technology, Kerman, Iran Solmaz Sarhadi sosa1360@yahoo.com 3200319475328460016427 3200319475328460016427 No Research Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, GraduateUniversity of Advanced Technology, Kerman, Iran Saeed Esmaeili-Mahani semahani@yahoo.com 3200319475328460016428 3200319475328460016428 Yes Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman