en Nervous system (others) Others Experimental research article Experimental research article <p dir="ltr" style="text-align: justify;"></p> <p dir="ltr" style="text-align: justify;"><span style="font-size: 12px;"><b>Introduction: </b><font face="Arial,Arial"><font face="Arial,Arial">There is evidence that diabetes affects seizure susceptibility. Ginger (</font></font><i><font face="Arial,Arial"><font face="Arial,Arial">Zingiber officinale </font></font></i><font face="Arial,Arial"><font face="Arial,Arial">Roscoe) which is used in traditional medicine has antioxidant activity and neuroprotective effects. The aim of this study was to evaluate the seizure threshold induced by pentylenetetrazole (PTZ) in diabetic mice after induction of diabetes with streptozocin and to examine the possible role of ginger extract in this manner. </font></font></span><span style="font-size: 12px;"><b>Methods: </b><font face="Arial,Arial"><font face="Arial,Arial">The anticonvulsant effect of ginger was investigated using </font></font><i><font face="Arial,Arial"><font face="Arial,Arial">i.v. </font></font></i><font face="Arial,Arial"><font face="Arial,Arial">PTZ-induced seizure models in non-diabetic and diabetic mice. Different doses of the hydroethanolic extract of ginger (50 and 100 mg/kg; i.p.) were administered daily for 2 weeks before PTZ challenge. The effect of ginger on the appearance of three separate seizure endpoints e.g. myoclonic, generalized clonic, and tonic extension phase were recorded. </font></font></span><span style="font-size: 12px;"><b>Results: </b><font face="Arial,Arial"><font face="Arial,Arial">The results showed that the ginger extract has anticonvulsant effects in the experimental model of seizure tested as it significantly increased the seizure threshold. Diabetic animal&rsquo;s shows high blood glucose level and lower seizure threshold compared with non-diabetic control animals. Hydroethanolic extract of ginger significantly increased the onset time of myoclonic seizure (</font></font><i><font face="Arial,Arial"><font face="Arial,Arial">p</font></font></i><font face="Arial,Arial"><font face="Arial,Arial"><0.001) and significantly prevented generalized clonic (</font></font><i><font face="Arial,Arial"><font face="Arial,Arial">p</font></font></i><font face="Arial,Arial"><font face="Arial,Arial"><0.001) and forelimb tonic extension (</font></font><i><font face="Arial,Arial"><font face="Arial,Arial">p</font></font></i><font face="Arial,Arial"><font face="Arial,Arial"><0.001) seizure induced by PTZ in both non-diabetic and diabetic animals compared with control group. </font></font></span><span style="font-size: 12px;"><b>Conclusion: </b><font face="Arial,Arial"><font face="Arial,Arial">Based on the results, the hydroethanolic extract of ginger has anticonvulsant effects in diabetic mice, possibly through hypoglycemic effect, antioxidant mechanisms, and oxidative stress inhibition.</font></font></span></p> Seizure, Ginger, Diabetes, PTZ, Mice 108 116 http://ppj.phypha.ir/browse.php?a_code=A-10-800-2&slc_lang=en&sid=1 Abdolkarim Hosseini ab_hosseini@sbu.ac.ir 3200319475328460016421 3200319475328460016421 No Department of Physiology, Faculty of Biological Science, Shahid Beheshti University, Tehran, Iran Naser Mirazi mirazi@basu.ac.ir 3200319475328460016422 3200319475328460016422 Yes Department of Biology, Faculty of Basic science, Bu-Ali Sina University, Hamedan, Iran Ali Gomar gomar.ucla@gmail.com 3200319475328460016423 3200319475328460016423 No Department of Biology, Science & Research Institute, Islamic Azad University, Tehran, Iran