Physiology and Pharmacology

en Association of two polymorphisms in MSH2 and XRCC1 genes with multiple sclerosis in Iranian population Cell, Stem Cell and Cancer Cell, Stem Cell and Cancer Experimental research article Experimental research article Introduction: To protect genomes of all organisms from internal and external damages and maintain the genome integrity and the continuity of life, repair system has been developed in all living cells. Defects in repair system are responsible for various kinds of disease including cancers and neurodegenerative diseases such as Multiple sclerosis (MS). The relationship between various components of the repair system and MS has been confirmed by investigations on separate cohorts in independent research. The main aim of this study was to discover the genetic association of two functional polymorphisms of rs1799782 in XRCC1 and rs2303425 in MSH2 genes as the key players in DNA repair system; with MS. Methods: The genotypes of 105 MS patients and 102 age and sex matched healthy controls for these polymorphisms were determined by a PCR-RFLP technique. Results: Genotype and allele frequencies of rs1799782 in patients with MS compared to the control group demonstrated a significant difference and a possible role for this polymorphism in MS pathogenesis (P value (0.02) and OR (3.4)). The rs2303425 polymorphism showed no significant correlation (P value = 0.41 and OR=1.5) with the risk of MS in Iranian population. Conclusion: Our results suggest a possible role for repair system genes and their significance in the pathogenesis of multiple sclerosis. DNA repair, Multiple Sclerosis, Association study, XRCC1, MSH2 83 89 http://ppj.phypha.ir/browse.php?a_code=A-10-486-3&slc_lang=en&sid=1 Zahra Abedi Kichi zahraabedi38@yahoo.com 3200319475328460016409 3200319475328460016409 No Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran Fatemeh Khani-Habibabadi f.khani90@yahoo.com 3200319475328460016410 3200319475328460016410 No Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran Mohammadali Sahraian sahraian1350@yahoo.com 3200319475328460016411 3200319475328460016411 No MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran Rosita Doosti sahraian150@yahoo.com 3200319475328460016412 3200319475328460016412 No MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran Mehrdad Behmanesh behmanesh@modares.ac.ir 3200319475328460016413 3200319475328460016413 Yes Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran