en Endocrine Physiology/Pharmacology Endocrine Physiology/Pharmacology Experimental research article Experimental research article <p dir="ltr" style="text-align: justify;"><span style="font-size: 12px;"><b>Introduction: </b><font face="Arial,Arial"><font face="Arial,Arial">Diabetes mellitus, as a chronic metabolic disease, is associated with a wide range of kidney and liver disorders. The goal of this study was to indicate the effects of selenium nanoparticles on the function of kidney and liver enzymes in stereptozocin induced diabetic rats. </font></font></span><span style="font-size: 12px;"><b>Methods: </b><font face="Arial,Arial"><font face="Arial,Arial">In this study, 35 male wistar rats were divided into five groups (n=7): control, diabetic control and three experimental groups receiving selenium nanoparticle solutions at doses of 0.1, 0.2 and 0.4 mg/kg/BW respectively. To induce diabetes in rats, a single dose of streptozocin (60 mg/kg/BW) was injected intraperitoneally. After the experimental period, blood samples were collected from all groups and the blood factors associated with the liver enzymes and kidney factors were measured and analyzed. </font></font></span><span style="font-size: 12px;"><b>Results: </b><font face="Arial,Arial"><font face="Arial,Arial">The results indicated that the levels of fasting blood sugar in all groups treated with selenium nanoparticles had a significant reduction compared to the diabetic group (</font></font><i><font face="Arial,Arial"><font face="Arial,Arial">P</font></font></i><font face="Arial,Arial"><font face="Arial,Arial">&le;0.05). Aspartate amino transferase had a significant reduction at the maximum dose compared to the diabetic group (</font></font><i><font face="Arial,Arial"><font face="Arial,Arial">P</font></font></i><font face="Arial,Arial"><font face="Arial,Arial">&le; 0.05). Also a significant decrease in the level of albumin was seen in the group treated with selenium nanoparticle (</font></font><i><font face="Arial,Arial"><font face="Arial,Arial">P</font></font></i><font face="Arial,Arial"><font face="Arial,Arial">&le; 0.05). Selenium nanoparticle treatment made a significant decreases in the levels of urea and ceratinine at the maximum dose (</font></font><i><font face="Arial,Arial"><font face="Arial,Arial">P</font></font></i><font face="Arial,Arial"><font face="Arial,Arial">&le; 0.05). </font></font></span><span style="font-size: 12px;"><b>Conclusion: </b><font face="Arial,Arial"><font face="Arial,Arial">The consumption of selenium nanoparticles in proper dosages may have beneficial effects on diabetic complications by lowering blood sugar as well as reducing the increased levels of the liver enzymes and kidney factors, albumin and cratinine resulting in the better function of kidney and liver. </font></font></span></p> Selenium, Nanoparticle, Liver enzymes, Diabetes 155 162 http://ppj.phypha.ir/browse.php?a_code=A-10-963-1&slc_lang=en&sid=1 Mahnaz Rezaei-Kelishadi m.rezaie81@yahoo.com 3200319475328460017776 3200319475328460017776 No Department of Biochemistry, Payame Noor University of Esfahan, Esfahan, Iran Ali Ghasemi alighasemi03@yahoo.com 3200319475328460017777 3200319475328460017777 No Department of Biochemistry, Payame Noor University of Esfahan, Esfahan, Iran Nasser Nabi Abdolyosefi naser_nabi88@yahoo.com 3200319475328460017778 3200319475328460017778 No Department of Biochemistry, Payame Noor University of Esfahan, Esfahan, Iran Setareh Zamani-Doabi sk_9678@yahoo.com 3200319475328460017779 3200319475328460017779 No Department of Biochemistry, Payame Noor University of Esfahan, Esfahan, Iran Majid Ramezani 3200319475328460017780 3200319475328460017780 No Department of Internal Medicine, Baghiatallah University of Medical Sciences, Tehran, Iran Saeed Changizi-Ashtiyani ashtiyani@sums.ac.ir 3200319475328460017781 3200319475328460017781 Yes Department of Physiology, Arak University of Medical Sciences, Arak, Iran Azar Rahimi ronak.r323@gmail.com 3200319475328460017782 3200319475328460017782 No Department of Biochemistry, Payame Noor University of Esfahan, Esfahan, Iran