en Endocrine Physiology/Pharmacology Endocrine Physiology/Pharmacology Experimental research article Experimental research article <p dir="ltr" style="text-align: justify;"><span style="font-size: 12px;"><b>Introduction: </b><font face="Arial,Arial"><font face="Arial,Arial">Diabetes is a multifactorial syndrome with high prevalence which may induce serious disorders in the body organs like the liver and kidney. This study aimed to compare the effects of the alcoholic extract of the aerial parts of </font></font><i><font face="Arial,Arial"><font face="Arial,Arial">Swertia longifolia Boiss </font></font></i><font face="Arial,Arial"><font face="Arial,Arial">on blood glucose, lipid profiles and liver and kidney function tests in streptozotocin-induced diabetes. </font></font></span><span style="font-size: 12px;"><b>Methods: </b><font face="Arial,Arial"><font face="Arial,Arial">Thirty five male rats were put into five groups: control, diabetic control and three diabetic experimental groups which were gavaged with alcoholic extract of </font></font><i><font face="Arial,Arial"><font face="Arial,Arial">Swertia longifolia Boiss </font></font></i><font face="Arial,Arial"><font face="Arial,Arial">at doses of 100 and 200 mg/kg BW and glibenclamide at a dose of 10 mg/kg BW, respectively. Diabetes was induced by intraperitoneal injection of streptozotocin. At the end of day 21 blood samples were collected from all groups and the blood factors were measured and analyzed. </font></font></span><span style="font-size: 12px;"><b>Results: </b><font face="Arial,Arial"><font face="Arial,Arial">The levels of creatinine, urea, liver enzymes, cholesterol and low density lipoprotein increased in the diabetic control group compared to the control, while the mentioned factors in the groups receiving </font></font><i><font face="Arial,Arial"><font face="Arial,Arial">Swertia longifolia Boiss </font></font></i><font face="Arial,Arial"><font face="Arial,Arial">alcoholic extract decreased significantly (</font></font><i><font face="Arial,Arial"><font face="Arial,Arial">P</font></font></i><font face="Arial,Arial"><font face="Arial,Arial"><0.05). In the experimental group receiving glibenclamide, the levels of creatinine, urea and lipid profiles also decreased, while the levels of liver enzymes and insulin significantly increased (</font></font><i><font face="Arial,Arial"><font face="Arial,Arial">P</font></font></i><font face="Arial,Arial"><font face="Arial,Arial"><0.05). </font></font></span><span style="font-size: 12px;"><b>Conclusion: </b><font face="Arial,Arial"><font face="Arial,Arial">The consumption of the alcoholic extract of the aerial parts of </font></font><i><font face="Arial,Arial"><font face="Arial,Arial">Swertia longifolia Boiss </font></font></i><font face="Arial,Arial"><font face="Arial,Arial">by lowering lipid profiles, liver enzymes, creatinine and urea as well as increasing insulin levels had beneficial effects on the hepatic and renal functions and could alleviate the symptoms of increased glucose and hyperlipidemia in diabetic rats.</font></font></span></p> Diabetes, Liver, Kidney, Streptozotocin, Swertia longifolia Boiss 163 171 http://ppj.phypha.ir/browse.php?a_code=A-10-963-2&slc_lang=en&sid=1 Ali Zarei zarei.ali40@gmail.com 3200319475328460017759 3200319475328460017759 No Department of Physiology, School of Nursing Hazrat Zahra (P.B.U.H) Abadeh, Shiraz University of Medical Sciences, Shiraz, Iran Ali Akbar Malekirad ak_malekirad@yahoo.com 3200319475328460017760 3200319475328460017760 Yes Department of Biology, Payame Noor University,Tehran, Iran Mohammad Abdollahi Mohammad.Abdollahi@UToronto.Ca 3200319475328460017761 3200319475328460017761 No Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran Gholamhassan Vaezi gh.vaezi@yahoo.com 3200319475328460017762 3200319475328460017762 No Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran Saeed Changizi-Ashtiyani ashtiyani@sums.ac.ir 3200319475328460017763 3200319475328460017763 No Department of Physiology, Arak University of Medical Sciences, Arak, Iran