Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1396
2
1
gregorian
2017
5
1
21
2
online
1
fulltext
en
Actors of necroptosis scenario in cell's scene
Cell, Stem Cell and Cancer
Cell, Stem Cell and Cancer
Review
Review
<p dir="ltr" style="text-align: justify;"><span style="font-size: 12px;">Necroptosis, as a novel concept, has been recently introduced in scientific literature. Much of our knowledge about necroptosis comes from ligation of tumor necrosis factor-α to its receptor, TNF receptor 1. Receptor-interacting protein kinase 1, receptor-interacting protein kinase 3 and its substrate, the pseudokinase mixed lineage kinase domain-like protein, have been comprehensively studied as influential components of this process. Emerging pioneering evidence suggests that many molecules, organelles and mechanisms are involved in necroptosis pathway. The aim of this review is presentation of molecular mechanisms of necroptosis in three phases including initiation, regulation and execution of necroptosis. Moreover, this review will summarize unprecedented insights into the contribution of various organelles and cell compartments such as mitochondria, endoplasmic reticulum, nucleus, lysosomes and Golgi apparatus in necroptosis pathway.</span></p>
Cell, Necroptosis, Organelles
88
101
http://ppj.phypha.ir/browse.php?a_code=A-11-975-1&slc_lang=en&sid=1
Sara
Nikseresht
sara.nikseresht@sbmu.ac.ir
3200319475328460017723
3200319475328460017723
Yes
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Fariba
Khodagholi
khodagholi@sbmu.ac.ir
3200319475328460017724
3200319475328460017724
No
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abolhassan
Ahmadiani
aahmadiani@yahoo.com
3200319475328460017725
3200319475328460017725
No
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran