Physiology and Pharmacology

en Effect of Syzygium aromaticum (clove) extract on seminiferous tubules and oxidative stress after testicular torsion in adult rats Others Others Experimental research article Experimental research article Introduction: The aim was to investigate the protective effect of the Syzygium aromaticum extract on damaged tissues and the oxidative stress after testicular torsion. Methods: Rats were randomly divided into a control group subjected to a sham procedure and three treatment groups comprising testicular torsion followed by detorsion (TD), testicular torsion detorsion followed by the treatment with an extract of Syzygium aromaticum (TDSA) and treatment done by extract of Syzygium aromaticum alone. Testicular torsion was induced by 720 degrees of counterclockwise rotation of the left testis for 4h. After the duration of the induction of the torsion, detorsion was done. The animals were given daily oral administrations of just Syzygium aromaticum (4 mg/kg) for seven days. The measurement of the oxidative stress and testosterone levels, as well as assessments of histomorphometry were conducted seven days after detorsion. Results: The Johnsen score, along with the thickness of the epithelium and diameter of the seminiferous tubules, significantly increased in the testicular torsion group after receiving treatment with the extract of Syzygium aromaticum as compared to TD group. The levels of testosterone and glutathione peroxidase activity also increased significantly in the TDSA compared to TD group. The MDA levels decreased in TDSA compared to TD group. Conclusion: The findings of the current study suggested that Syzygium aromaticum might have provided a protective effect against testicular torsion detorsion injury. Syzygium aromaticum, Clove , Oxidative stress, Testicular torsion 343 350 http://ppj.phypha.ir/browse.php?a_code=A-10-988-1&slc_lang=en&sid=1 Maryam Moghimian moghimian.m@gmu.ac.ir 3200319475328460018624 3200319475328460018624 No Department of Basic Sciences, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Islamic Republic of Iran Seyd-Hosein Abtahi-Evari abtahi.h@gmu.ac.ir 3200319475328460018625 3200319475328460018625 No Department of Basic Sciences, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Islamic Republic of Iran Majid Shokoohi a.shokooh@yahoo.com 3200319475328460018626 3200319475328460018626 No Department of Basic Sciences, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Islamic Republic of Iran Mostafa Amiri amiri.m@gmu.ac.ir 3200319475328460018627 3200319475328460018627 No Department of Basic Sciences, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Islamic Republic of Iran Malihe Soltani m.soltani@gmu.ac.ir 3200319475328460018628 3200319475328460018628 Yes Department of Basic Sciences, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Islamic Republic of Iran