en Gastrointestinal Physiology/Pharmacology Gastrointestinal Physiology/Pharmacology Experimental research article Experimental research article <p dir="ltr" style="text-align: justify;"><span style="font-size: 12px;"><span style="font-size: 12px;"><b>Introduction: </b><font face="Arial,Arial"><font face="Arial,Arial">Sodium hydrosulfide (NaHS) has shown to enhance the gastric emptying rate in normal rats but till now its effect on gastric emptying of food stuffs in diabetic rats was not investigated. Therefore, this study designed to determine the role of an oral administration of NaHS on gastric emptying rate (GER) of glucose, albumin and olive oil in gastroparetic and normal rats. <span style="font-size: 12px;"><b>Methods: </b><font face="Arial,Arial"><font face="Arial,Arial">To evaluate the effect of NaHS on the gastric emptying of glucose, albumin and olive oil in normal rats, thirty-six normal rats randomly assigned in six experimental groups (6 per group). Three groups of rats considered as control. They received albumin, glucose or olive oil orally. Three other normal groups considered as NaHS-treated animals. These groups received NaHS (320 &mu;g/kg, orally) 30 min prior to food stuffs. To investigate the effect of NaHS on the gastric emptying of food stuffs in diabetic rats, the same protocols carried out. Thirty min after intragastric administration of food stuffs, animals received acetaminophen (as a marker for gastric emptying rate). <span style="font-size: 12px;"><b>Results: </b><font face="Arial,Arial"><font face="Arial,Arial">The results showed that in normal and gastroparetic rats, an oral administration of NaHS accelerated gastric emptying of glucose, albumin and olive oil. The increased gastric emptying of glucose, albumin and olive oil in NaHS-pretreated gastroparetic rats was 89.9, 92.3 and 60% respectively more than in corresponding&rsquo;s controls. </font></font></span></font></font></span></font></font></span></span></p> Sodium hydrosulfide, Gastric emptying rate, Gastroparesis, Diabetic rat 234 240 http://ppj.phypha.ir/browse.php?a_code=A-10-993-1&slc_lang=en&sid=1 Seyyed Ali Mard mard-sa@ajums.ac.ir 3200319475328460018189 3200319475328460018189 Yes Research Center for Infectious Diseases of Digestive System [Alimentary Tract Research Center], Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Iraj Ahmadi ahmadiiraj57@yahoo.com 3200319475328460018190 3200319475328460018190 No Research Center for Infectious Diseases of Digestive System [Alimentary Tract Research Center], Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Mohammad Kazem Gharib-Naseri mgharibnaseri@yahoo.com 3200319475328460018191 3200319475328460018191 No Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Feryal Savary savari.f@ajums.ac.ir 3200319475328460018192 3200319475328460018192 No Research Center for Infectious Diseases of Digestive System [Alimentary Tract Research Center], Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran