en Pharmacokinetics/Dynamics Pharmacokinetics/Dynamics Experimental research article Experimental research article <span style="font-size: 12px;"><p align="LEFT"></p></span> <p style="text-align: justify;"><span style="font-size: 12px;"><b>Introduction: </b><font face="Arial,Arial"><font face="Arial,Arial">In this study, we evaluated the antidiabetic and antidiabetogenic effect of saffron against diabetes induced by artificial dye tartrazine on normal male rats. </font></font></span></p> <p style="text-align: justify;"><span style="font-size: 12px;"><b>Methods: </b><font face="Arial,Arial"><font face="Arial,Arial">Dried saffron was macerated for 12 hours in distilled water before usage and crude extract was used to treat male rats. Rats were divided into 5 groups consisted of 6 rats and treatment was performed daily and orally. Group-1 treated with distilled water, group-2 with tartrazine 10mg/kg followed by saffron 120mg/kg until the last day of treatment, group-3 administered with tartrazine, group-4 treated with saffron for 60 days and administered with tartrazine, group-5 with saffron for 105 days. Levels of blood glucose and body weight have been evaluated every 10 days and clinical demonstrations and metabolic parameters were evaluated at the end of the experiment. <b>Results: </b><font face="Arial,Arial"><font face="Arial,Arial">Levels of blood glucose and body weight have been evaluated every 10 days and clinical demonstrations and metabolic parameters were evaluated at the end of the experiment. Results showed that treatment with tartrazine and saffron did not affect body weights, metabolic parameters but changed the blood glucose levels after 105 days of administration. The levels of glucose and creatinine were significantly increased in group-2 and group-3 compared to control group (</font></font><i><font face="Arial,Arial"><font face="Arial,Arial">P</font></font></i><font face="Arial,Arial"><font face="Arial,Arial"><0.05). There was no significant difference in the level of glucose, creatinine in group4 (</font></font><i><font face="Arial,Arial"><font face="Arial,Arial">P</font></font></i><font face="Arial,Arial"><font face="Arial,Arial">>0.05). Treatment with saffron decreases creatinine level. <b>Conclusion: </b><font face="Arial,Arial"><font face="Arial,Arial">The outcomes suggest that saffron has curative (antidiabetic) and protective (antidiabetogenic) effect against diabetes induced by tartrazine via reducing blood glucose level and creatinine. Therefore, it should be considered in future therapeutic researches.</font></font></font></font></font></font></span></p> Crocus sativus L., Antidiabetic effect, Antidiabetogenic effect, Tartrazine, Saffron 312 321 http://ppj.phypha.ir/browse.php?a_code=A-10-998-1&slc_lang=en&sid=1 Iliass Lahmass i.lahmass@ump.ac.ma 3200319475328460018608 3200319475328460018608 Yes Université Mohamed Premier, Faculty of Sciences, Department of Biology, Laboratory of Biochemistry, Oujda, Morocco Assia Sabouni a.sabouni@ump.ac.ma 3200319475328460018609 3200319475328460018609 No Université Mohamed Premier, Faculty of Sciences, Department of Biology, Laboratory of Biochemistry, Oujda, Morocco Mohammed Elyoubi m.elyoubi@ump.ac.ma 3200319475328460018610 3200319475328460018610 No Université Mohamed Premier, Faculty of Sciences, Department of Biology, Laboratory of Biochemistry, Oujda, Morocco Redouane Benabbes r.benabbes@ump.ac.ma 3200319475328460018611 3200319475328460018611 No Université Mohamed Premier, Faculty of Sciences, Department of Biology, Laboratory of Biochemistry, Oujda, Morocco Slimane Mokhtari s.moukhtari@ump.ac.ma 3200319475328460018612 3200319475328460018612 No Regional Laboratory of Medical Analysis, Hôpital Al Farabi, Oujda, Morocco Ennouamane Saalaoui e.saalaoui@ump.ac.ma 3200319475328460018613 3200319475328460018613 No Université Mohamed Premier, Faculty of Sciences, Department of Biology, Laboratory of Biochemistry, Oujda, Morocco