en Cardiovascular Physiology/Pharmacology Cardiovascular Physiology/Pharmacology Experimental research article Experimental research article <span style="font-size: 12px;"><p align="LEFT"></p></span> <p style="text-align: justify;"><span style="font-size: 12px;"><b>Introduction: </b><font face="Arial,Arial"><font face="Arial,Arial">Mutations in the delta sarcoglycan gene (d-SG) cause limb-girdle muscular dystrophy type 2F with structural and functional alterations in cardiac, smooth and skeletal muscle. The objective of the present study was to improve information about changes in vascular reactivity of the thoracic aorta and the coronary artery in the perfused heart of the d-SG-null mutant mouse model. <b>Methods: </b><font face="Arial,Arial"><font face="Arial,Arial">Female knockout (KO) and wild-type (WT) mice (5 months old) with and without nitric oxid and prostanoids antagonist were used. Curves doses response to phenylephrine, angiotensin II and acetylcholine were constructed. <b>Results: </b><font face="Arial,Arial"><font face="Arial,Arial">The results shows an increment in the contractile response to angiotensin II in the aorta and the isolated heart from the KO mice, and it seems due to a major participation of prostanoids. On the other hand the relaxant effect of acetylcholine is less in the KO than in the WT mice. <b>Conclusion: </b><font face="Arial,Arial"><font face="Arial,Arial">Changes in vascular reactivity in KO mice seems due to the participation of prostanoids instead of nitric oxide.</font></font></font></font></font></font></font></font></span></p> Delta sarcoglycan gene, Vascular reactivity, Aorta, Heart 322 330 http://ppj.phypha.ir/browse.php?a_code=A-10-1014-1&slc_lang=en&sid=1 Maria C. Castillo-Hernandez rcoral@ipn.mx 3200319475328460018651 3200319475328460018651 No Instituto Politécnico Nacional, Escuela Superior de Medicina, Sección de Estudios de Posgrado e Investigación, México Gustavo Guevara-Balcazar gguevarab@ipn.mx 3200319475328460018652 3200319475328460018652 No Instituto Politécnico Nacional, Escuela Superior de Medicina, Sección de Estudios de Posgrado e Investigación, México Alexandre Kormanovski 3200319475328460018653 3200319475328460018653 No Instituto Politécnico Nacional, Escuela Superior de Medicina, Sección de Estudios de Posgrado e Investigación, México Ivan Rubio Gayosso aiorubio@ipn.mx 3200319475328460018654 3200319475328460018654 No Instituto Politécnico Nacional, Escuela Superior de Medicina, Sección de Estudios de Posgrado e Investigación, México Ramon M. Coral-Vazquez ccastillohe@ipn.mx 3200319475328460018655 3200319475328460018655 Yes Instituto Politécnico Nacional, Escuela Superior de Medicina, Sección de Estudios de Posgrado e Investigación, México