Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1396
12
1
gregorian
2018
3
1
22
1
online
1
fulltext
en
Executive functions are related to serum testosterone and basal metabolism rate fluctuation but not lymphocyte dopamine receptor expression in the young healthy participants
Learning and Memory
Neurophysiology/Pharmacology
Experimental research article
Experimental research article
<div style="text-align: justify;"><span style="font-size: 12px;">Introduction: Herein, we evaluated linkages between EFs performances and dopamine receptor (DR) mRNA and testosterone level in the young Iranian male people. <span style="font-size: 12px;">Methods: All 140 participants were normalized using depression, anxiety and stress scale questionnaire. Remained 108 volunteers were tested against drug abuse and then volunteers were distinguished by Wisconsin Card Sorting Test (WSCT). According to WCST, participants were divided into two low and high EFs performance. Afterward, anthropometric factors, body mass index (BMI) and serum testosterone level were measured in low and high EFs groups. Blood samples were collected, and biochemical and anthropometric data were evaluated; serum testosterone and DR mRNA expression were assessed in participants. Results: Data showed there are no differences between two groups in Na<sup>+</sup>, K<sup>+</sup>, glucose, urea, creatinine, SGPT, SGOT and other biochemical serum agents (P>0.05) but BMI was increased in low EFs compared with high EFs (P=0.000). Interestingly, there is no difference in DR expression between two groups (P>0.05). Conclusion: Our data presented that fluctuation of EFs performances in healthy adult male cases might depend on BMI and serum testosterone; while dopamine receptors in the blood lymphocytes had no substantial role in the EFs. High serum testosterone reduced EFs in the young adults.</span></span></div>
Executive function, Dopamine receptor, Testosterone, Young people, Blood lymphocytes, Body mass index
1
10
http://ppj.phypha.ir/browse.php?a_code=A-10-73-125&slc_lang=en&sid=1
Mitra-Sadat
Sadat-Shirazi
mitrasadat@gamil.com
3200319475328460019125
3200319475328460019125
No
Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Ghorbangol
Ashabi
as_habi@yahoo.com
3200319475328460019126
3200319475328460019126
No
Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Nima
Babhadiashar
bobhadiashar@yahoo.com
3200319475328460019127
3200319475328460019127
No
Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran
Mohammadreza
Bahrami Hessari
Bahrami@gmail.com
3200319475328460019128
3200319475328460019128
No
Faculty of Psychology & Education, Allameh Tabataba'i University, Tehran, Iran
Nasim
Vousooghi
dr.n.vosoughi@gmail.com
3200319475328460019129
3200319475328460019129
No
Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Mohammad-Reza
Zarrindast
zarinmr@ams.ac.ir
3200319475328460019130
3200319475328460019130
Yes
Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran