en Endocrine Physiology/Pharmacology Endocrine Physiology/Pharmacology Experimental research article Experimental research article <span style="font-size: 12px;"><p align="LEFT"></p></span> <p style="text-align: justify;"><span style="font-size: 12px;"><b>Introduction: </b><font face="Arial,Arial"><font face="Arial,Arial">The aim of the present study was to evaluate the preventive effects of Flavin7 in prediabetic bio-breeding diabetes prone (BB-DP) rats. <b>Methods: </b><font face="Arial,Arial"><font face="Arial,Arial">Foutthy rats were divided into 2 equal groups: group C (untreated control group) and group F7 with Flavin7 (natural dietary supplement F7 with bioflavonoids, 0.2 mg/l) in drinking water from 21</font></font><font face="Arial,Arial"><font face="Arial,Arial">st </font></font><font face="Arial,Arial"><font face="Arial,Arial">day after birth to 171</font></font><font face="Arial,Arial"><font face="Arial,Arial">st </font></font><font face="Arial,Arial"><font face="Arial,Arial">day of their life, respectively. Blood glucose, superoxide dismutase, glutathione peroxidase, catalase, total antioxidant capacity, glutathione, body weight, food intake, water intake and urine output were determined.<b>&nbsp; Results: </b><font face="Arial,Arial"><font face="Arial,Arial">The age of diabetes onset was significantly higher for group F7 compared to group C (</font></font><i><font face="Arial,Arial"><font face="Arial,Arial">P</font></font></i><font face="Arial,Arial"><font face="Arial,Arial"><0.05). The incidence of diabetes was lower in group F7 than in group C. Blood glucose at the diabetes onset was higher in group C than in F7 group (</font></font><i><font face="Arial,Arial"><font face="Arial,Arial">P</font></font></i><font face="Arial,Arial"><font face="Arial,Arial"><0.05). Decrease of antioxidant status parameters, at the treatment onset as well as immediately after its termination showed a drop in the F7 group firstly, but increased progressively later, until the end of the experiment. <b>Conclusion: </b><font face="Arial,Arial"><font face="Arial,Arial">F7 delayed the development of diabetes in BB-DP rats and prevented its onset. The severity of diabetes mellitus was milder in rats treated with F7 than in control group. </font></font></font></font></font></font></font></font></span></p> Type 1 diabetes mellitus, BB-DP rats, Flavin7, Prevention of diabetes 11 18 http://ppj.phypha.ir/browse.php?a_code=A-10-1050-1&slc_lang=en&sid=1 František Ništiar frantisek.nistiar@upjs.sk 3200319475328460019131 3200319475328460019131 No Institute of Pathological Physiology, Faculty of Medicine, Šafárik University, Košice, Slovak Republic Agnesa Lukačínová agnesa.lukacinova1@upjs.sk 3200319475328460019132 3200319475328460019132 No Institute of Medical Physiology, Faculty of Medicine, Šafárik University, Košice, Slovak Republic Oliver Rácz oliver.racz@upjs.sk 3200319475328460019133 3200319475328460019133 No Institute of Pathological Physiology, Faculty of Medicine, Šafárik University, Košice, Slovak Republic Jaroslava Nováková jaroslava.novakova@upjs.sk 3200319475328460019134 3200319475328460019134 No Institute of Pathological Physiology, Faculty of Medicine, Šafárik University, Košice, Slovak Republic Eva Lovásová eva.lovasova@upjs.sk 3200319475328460019135 3200319475328460019135 No Institute of Pathological Physiology, Faculty of Medicine, Šafárik University, Košice, Slovak Republic Marek Brenišin marek.brenisin@upjs.sk 3200319475328460019136 3200319475328460019136 Yes Institute of Pathological Physiology, Faculty of Medicine, Šafárik University, Košice, Slovak Republic Simona Rusnáková simona.rusnakova@student.upjs.sk 3200319475328460019137 3200319475328460019137 No Institute of Pathological Physiology, Faculty of Medicine, Šafárik University, Košice, Slovak Republic