en Neurophysiology/Pharmacology Neurophysiology/Pharmacology Experimental research article Experimental research article <span style="font-size: 12px;"><p align="LEFT"></p></span> <p style="text-align: justify;"><span style="font-size: 12px;"><span style="color: rgb(0, 0, 0);"><b>Introduction: </b><font face="Arial,Arial"><font face="Arial,Arial">Epilepsy is one of the most common and chronic neurological disorders. It appears periodically and usually is concomitant with unpredictable seizures due to abnormal discharge of brain neurons. In this study, we investigated the anticonvulsant effect of ascorbic acid (AA) on seizures induced by pentylenetetrazole (PTZ) in male rats. <span style="color: rgb(0, 0, 0);"><font face="Arial,Arial"><font face="Arial,Arial"><font face="Arial,Arial"><b>Methods: </b></font></font></font><font face="Arial,Arial"><font face="Arial,Arial">In this study PTZ (37 mg/kg) was injected every other day to induce kindling in male rats. AA (12.5, 25 and 50 mg/kg) was administered into the right lateral ventricle 30 minute before every PTZ injection. The seizure parameters were measured during 30 min after PTZ injection. <span style="color: rgb(0, 0, 0);"><font face="Arial,Arial"><font face="Arial,Arial"><font face="Arial,Arial"><b>Results: </b></font></font></font><font face="Arial,Arial"><font face="Arial,Arial">Administration of 12.5 mg/kg of AA increased stage 4 latency compared to vehicle group. Conversely, 50 mg/kg of AA decreased stage 1 and 2 latency, increased stage 5 duration and decreased number of PTZ injections needed to achieve stage 5 seizure compared to vehicle treated animals. <span style="color: rgb(0, 0, 0);"><font face="Arial,Arial"><font face="Arial,Arial"><font face="Arial,Arial"><b>Conclusion: </b></font></font></font><font face="Arial,Arial"><font face="Arial,Arial">It seems that the AA has dual effects on seizure parameters induced by PTZ. Low doses (12.5 mg/kg) have protective effects while high doses (50 mg/kg) have proconvulsant effects on seizure.</font></font></span></font></font></span></font></font></span></font></font></span></span></p> Ascorbic acid, Epilepsy, Pentylenetetrazole, Rat 103 108 http://ppj.phypha.ir/browse.php?a_code=A-10-182-3&slc_lang=en&sid=1 Batool Kamali manesh kamalimaneshb961@mums.ac.ir 3200319475328460019402 3200319475328460019402 No Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran Ehsan Mohebi MohebiE@medsab.ac.ir 3200319475328460019403 3200319475328460019403 No Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran Hassan Azhdari Zarmehri azhdarih1@thums.ac.ir 3200319475328460019404 3200319475328460019404 No Department of Basic sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran Ali Shamsizadeh ashamsi@rums.ac.ir 3200319475328460019405 3200319475328460019405 No Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Mohammad Mohammad-Zadeh mohammadzadehmh@mums.ac.ir 3200319475328460019406 3200319475328460019406 Yes Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran