en Renal Physiology/Pharmacology Renal Physiology/Pharmacology Experimental research article Experimental research article <div style="text-align: justify;"><strong>Introduction:</strong> One of the main reasons for acute renal failure is the renal ischemiareperfusion. It seems that renal ischemia-reperfusion-induced oxidative stress not only lead to alterations in renal function but also causes tissue alterations in distant organs such as the liver. The purposes of this study were to investigate the effects of renal ischemia-reperfusion on biochemical factors and histopathological changes in the liver of male rats. <strong>Methods:</strong> Forty male rats were randomly divided into 4 groups: control, the sham group (only laparotomy), right nephrectomy and ischemic-reperfusion (right nephrectomy + left ischemic- reperfusion). In the end, following anesthesia, blood and liver samples were taken for the measurement of biochemical factors (malondialdehyde (MDA), superoxide dismutase (SOD), aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT) levels) and histopathological changes.<strong> Results:</strong> The result of this study indicated that renal ischemia-reperfusion significantly decreased SOD and increased MDA, AST, ALP and ALT compared to sham-control group (P<0.05). In addition, histopathological findings show that ischemia-reperfusion significantly increased apoptotic cells (P<0.05) and causes the disorganized arrangement of the hepatic plate, severe hepatocellular cytoplasmic vacuolation and extensive nuclear pyknosis. <strong>Conclusion:</strong> Our findings suggest that renal ischemia-reperfusion-induced liver damage, accompanied by decreasing of antioxidant capacity and increasing of oxidative stress and apoptosis in the liver.</div> Renal ischemia-reperfusion, Oxidative Stress, Liver, Biochemical factors, Histopathological alterations. 44 50 http://ppj.phypha.ir/browse.php?a_code=A-10-1136-1&slc_lang=en&sid=1 Hadi Yousefi yousefi@tbzmed.ac.ir 3200319475328460029544 3200319475328460029544 No Khoy University of Medical Sciences, Khoy, Iran Nasser Ahmadiasl ahmadyn@tbzmed.ac.ir 3200319475328460029545 3200319475328460029545 No Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Ramin Salimnejad r.salimnejad@arums.ac.ir 3200319475328460029546 3200319475328460029546 No Research Laboratory for Embryology and Stem Cells, Department of Anatomical Sciences and Pathology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran Elhameh Bagheri bagheri@tbzmed.ac.ir 3200319475328460029547 3200319475328460029547 No Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Leila Roshangar roshangar@tbzmed.ac.ir 3200319475328460029548 3200319475328460029548 No Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Alireza Alihemmati hemmati@tbzmed.ac.ir 3200319475328460029549 3200319475328460029549 Yes Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran