en Neurophysiology/Pharmacology Neurophysiology/Pharmacology Experimental research article Experimental research article <div style="text-align: justify;"><strong>Introduction:</strong> Given that pelargonidin is an anthocyanin that exhibits neuroprotective effects and Alzheimer&#39;s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-beta (A&beta;) and cognitive dysfunction subsequently, herein, we examined the effects of pelargonidin on A&beta;-induced long-term potentiation deficits in rats. <strong>Methods:</strong> AD was induced using intrahippocampal injections of the A&beta; in the adult Wistar male rats. The rats received single intraperitoneal injections of pelargonidin (3mg/kg). Long-term potentiation in the perforant path- dentate gyrus synapses was assessed electrophysiologically by measuring the field excitatory post-synaptic potential (fEPSP) slope and population spike (PS) amplitude. <strong>Results:</strong> Our results showed that A&beta; significantly decreased fEPSP slope and SP amplitude in comparison with the control and sham groups, whereas pelargonidin increased these parameters in comparison to the A&beta; group. <strong>Conclusion:</strong> It is probably that pelargonidin could improve A&beta;-induced cognition deficit in rats.</div> Amyloid β-peptide, Pelargonidin, Long- term potentiation, Hippocampus. 296 301 http://ppj.phypha.ir/browse.php?a_code=A-10-1206-1&slc_lang=en&sid=1 Sara Soleimani Asl 3200319475328460029660 3200319475328460029660 No Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Marek J. Łos 3200319475328460029661 3200319475328460029661 No Małopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland Mehdi Mehdizadeh mehdizadeh.m@iums.ac.ir 3200319475328460029662 3200319475328460029662 Yes Cellular and Molecular Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran