Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1399
9
1
gregorian
2020
12
1
24
4
online
1
fulltext
en
Protective effect of zinc sulfate and continuous/interval training on liver oxidative stress in morphine-withdrawal syndrome in rats
Others
Others
Experimental research article
Experimental research article
<div style="text-align: justify;"><strong>Introduction:</strong> In this study, the effect of zinc sulfate (ZS) supplement and eight-week continuous training (CT) and interval training (IT) on liver oxidative stress of morphine-dependent rats following withdrawal syndrome (WS) were evaluated. <strong>Methods:</strong> Seventy Wistar rats were randomly divided into seven groups: control rats, withdrawing rats (WS), withdrawing rats receiving 9mg/kg ZS orally (WS+Z), withdrawing rats under CT (WS+CT), withdrawing rats under IT (WS+IT), withdrawing rats under CT and receiving 9mg/kg zinc sulfate (WS+Z+CT), withdrawing rats under IT and receiving 9mg/kg zinc sulfate (WS+Z+IT). Animals were addicted by 0.4g/l morphine sulfate in 21 days. Animals in the training groups ran on a treadmill and received ZS 5 days/week for 8 weeks. At the end of the study, oxidative stress in liver tissue and liver enzymes were measured by spectrophotometric and ELISA methods. <strong>Results:</strong> ZS supplement, CT/IT led to decrease DNA damage and malondialdehyde in comparison with morphine group. Also, ZS, CT and IT significantly elevated levels in superoxide dismutase, catalase activity, total antioxidant capacity and thiol groups in the liver of rats in comparison with morphine group. Additionally, it is observed that ZS and CT/IT made a significant reduction in aspartate aminotransferase levels in comparison to the morphine group. <strong>Conclusion:</strong> CT/IT with ZS because of its antioxidant effects has the potential to be used for decreased withdrawal syndrome complications.</div>
Zinc Sulfate, Continuous Training, Interval Training, Morphine, Withdrawal Syndrome, Liver.
276
284
http://ppj.phypha.ir/browse.php?a_code=A-10-1258-2&slc_lang=en&sid=1
Sahar
Hasani
3200319475328460029483
3200319475328460029483
No
Student Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Hassan
Ghasemi
3200319475328460029484
3200319475328460029484
No
Department of Clinical Biochemistry, Abadan School of Medical Sciences, Abadan, Iran
Akram
Ranjbar
3200319475328460029485
3200319475328460029485
No
Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
Reza
Ghahremani
3200319475328460029486
3200319475328460029486
No
Department of Exercise Physiology, Faculty of Sport Sciences, University of Birjand, Birjand, Iran
Ali
Heidarianpour
3200319475328460029487
3200319475328460029487
No
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamadan, Iran
Hadis
Abotalebian
3200319475328460029488
3200319475328460029488
No
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
Alireza
Gharib
3200319475328460029489
3200319475328460029489
No
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Nejat
Kheiripour
kheiripour-n@kaums.ac.ir
3200319475328460029490
3200319475328460029490
Yes
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran