Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1399
3
1
gregorian
2020
6
1
24
2
online
1
fulltext
en
Immunohistochemical evidence for involvement of inflammatory cytokines in anti-arrhythmic effects of rosuvastatin in male rats
Cardiovascular Physiology/Pharmacology
Cardiovascular Physiology/Pharmacology
Experimental research article
Experimental research article
<div style="text-align: justify;"><strong>Introduction:</strong> Considering the cardioprotective and anti-inflammatory properties of statins, the aim of the present experiment was to investigate the possible involvement of inflammatory cytokines in anti-arrhythmic effects of rosuvastatin in both in vitro and in vivo experiments in rats. <strong>Methods:</strong> Three weeks after oral administration of either of rosuvastatin or vehicle, the atria were removed and after incubation with ouabain, time of onset of arrhythmia and asystole were recorded. We also used immunohistochemistry technique to identify the differentially expressed proteins interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α in atria. <strong>Results:</strong> Rosuvastatin significantly postponed the onset of arrhythmia compared to vehicle-treated group. Injection of ouabain increased the atrial expression of IL-1β, IL-6 and TNF-α proteins, while pretreatment of rats with rosuvastatin could significantly attenuate them. <strong>Conclusion:</strong> Our data suggest that rosuvastatin exerts anti-arrhythmic properties at least in part through modulation of inflammatory cytokines.</div>
Rosuvastatin, Cardiovascular, Arrhythmia, Inflammatory cytokines.
142
151
http://ppj.phypha.ir/browse.php?a_code=A-10-1298-1&slc_lang=en&sid=1
Sima
Amini
3200319475328460029423
3200319475328460029423
No
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Vahid
Nikoui
3200319475328460029424
3200319475328460029424
No
Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran
Farahnaz
Jazaeri
3200319475328460029425
3200319475328460029425
No
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Muhammad
Imran Khan
3200319475328460029426
3200319475328460029426
No
Department of Pharmacy, Kohat University of Science and Technology, 26000 Kohat, Pakistan
Alireza
Partoazar
3200319475328460029427
3200319475328460029427
No
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
Azam
Bakhtiarian
bakhtiar@tums.ac.ir
3200319475328460029428
3200319475328460029428
Yes
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran