Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61882/phypha
(previous ISSN: 17350581)
en
jalali
1399
9
1
gregorian
2020
12
1
24
4
online
1
fulltext
en
Treadmill exercise improves memory and increases hippocampal BDNF in a rat model of Alzheimer's Disease
Neurophysiology/Pharmacology
Neurophysiology/Pharmacology
Experimental research article
Experimental research article
<div style="text-align: justify;"><strong>Introduction:</strong> Alzheimer’s disease is strongly correlated with learning and memory impairments. As exercise can enhance memory and learning, in this study, we have investigated the effects of treadmill exercise on memory impairment in amyloid β (Aβ)- treated rats focusing on brain-derived neurotrophic factor (BDNF) expression. <strong>Methods:</strong> Wistar male rats received intracerebroventricular (ICV) injection of Aβ and exercised on a treadmill for one month. Memory function was assessed using Morris water maze (MWM) and avoidance learning tasks. The level of BDNF was examined by the ELISA test. <strong>Results:</strong> The results of MWM and avoidance learning tasks showed that treadmill exercise could improve Aβ- induced memory impairment significantly. Moreover, BDNF expression increased following exercise in the Aβ- treated rats. <strong>Conclusion:</strong> The present results suggested that treadmill exercise may improve memory in Alzheimer’s disease by increasing BDNF level in the hippocampus.</div>
Treadmill exercise, Alzheimer’s disease, Memory, BDNF.
250
256
http://ppj.phypha.ir/browse.php?a_code=A-10-1195-2&slc_lang=en&sid=1
Rokhsareh
Abshenas
3200319475328460029471
3200319475328460029471
No
Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran
Tayebe
Artimani
3200319475328460029472
3200319475328460029472
No
Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran
Iraj
Amiri
3200319475328460029473
3200319475328460029473
No
Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran
Siamak
Shahidi
3200319475328460029474
3200319475328460029474
No
Physiology Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Sara
Soleimani Asl
s.soleimaniasl@umsha.ac.ir
3200319475328460029475
3200319475328460029475
Yes
Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran