Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1400
6
1
gregorian
2021
9
1
25
3
online
1
fulltext
en
Topical formulation of tranilast improves hypertrophic scar in a rat model
Cell, Stem Cell and Cancer
Cell, Stem Cell and Cancer
Experimental research article
Experimental research article
<div style="text-align: justify;"><strong>Introduction:</strong> Hypertrophic scars are dermal complication that may lead to considerable morbidity. There is an intense medical need for novel therapies for this disease. Tranilast is an anti-allergic agent that clinically used for the treatment of keloids and hypertrophic scars. In this study, we aimed to evaluate the effect of tranilast 0.5% topical formulation on hypertrophic scars resulted by burn injury in rats. <strong>Methods:</strong> Burn wounds were inflicted on the skin area of the backs of all rats, following that the scars are created, treatment started and continued for 28 days. Animals were divided into two groups (n=8): the control scar group, which received a placebo and the treatment group that received 0.5% tranilast gel. After this period, skin biopsies were collected from each group for the following analyses. The tissue samples were analyzed by hematoxylin-eosin, Masson’s trichrome staining and qRT-PCR. <strong>Results: </strong>Histologically, topical tranilast reduced hypertrophic scar signs as compared to placebo. Tranilast treatment also resulted in a reduction in type I and III collagen, transforming growth factor-beta1, Smad2 and vascular endothelial growth factor , and increased Smad7 mRNA expression in the skin scar site. <strong>Conclusion:</strong> These findings showed that the 0.5% tranilast topical gel could be effective in the treatment of hypertrophic scars in a rat experiment.</div>
Tranilast, Hypertrophic scar, Wound healing, Topical formulation.
242
250
http://ppj.phypha.ir/browse.php?a_code=A-10-1425-1&slc_lang=en&sid=1
Sara
Darakhshan
3200319475328460029292
3200319475328460029292
No
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Fereshteh
Bagheri
3200319475328460029293
3200319475328460029293
No
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Seyran
Kakabaraei
3200319475328460029294
3200319475328460029294
No
Department of Anatomical Sciences & Cell Biology, Kermanshah University of Medical Sciences, Kermanshah, Iran
Reza
Tahvilian
rtahvilian@kums.ac.ir
3200319475328460029295
3200319475328460029295
Yes
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran