en Pharmacokinetics/Dynamics Pharmacokinetics/Dynamics Short communication Short communication <div style="text-align: justify;"><strong><span class="fontstyle0">Introduction: </span></strong><span class="fontstyle2">This study evaluated the anticonvulsant activity of the add-on </span><span class="fontstyle3">Drimia maritima </span><span class="fontstyle2">(squill) oxymel, used traditionally in the treatment of convulsion, in animal model. </span><span class="fontstyle0"><strong>Methods:</strong> </span><span class="fontstyle2">Albino mice pretreated with squill oxymel in different doses of 50, 100, 200 and 400mg/kg by oral gavage, 15min prior to injection of pentylenetetrazole (PTZ). Animals pretreated with flumazenil to determine the mechanism of anticonvulsant action. The total flavonoid content of squill oxymel was also determined.<strong> </strong></span><span class="fontstyle0"><strong>Results:</strong> </span><span class="fontstyle2">Squill oxymel prolonged the onset of seizures and decreased the duration of seizures compared to control group. Diazepam used as a reference drug for its anticonvulsive effects, showed complete inhibition of seizure. This study revealed that squill oxymel has significant anticonvulsant effect in PTZ-induced seizures in mice and these effects may be related to its effect on benzodiazepines&rsquo; receptors on GABA complex. </span><span class="fontstyle0"><strong>Conclusion:</strong> </span><span class="fontstyle2">These results confirmed the traditional use of squill oxymel in Iranian traditional medicine for treatment of epilepsy. The clarification of mechanisms involved needs further studies.</span></div> Drimia maritime, Squill, Oxymel, Anticonvulsant, Pentylenetetrazole 1 6 http://ppj.phypha.ir/browse.php?a_code=A-15-1428-2&slc_lang=en&sid=1 Meysam Abolmaali 3200319475328460030953 3200319475328460030953 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Manijeh Motevalian 3200319475328460030954 3200319475328460030954 No Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Saeed Mehrzadi 3200319475328460030955 3200319475328460030955 No Razi Drug Research Centre, Iran University of Medical Sciences, Tehran, Iran Asie Shojaii shojaii.a@iums.ac.ir 3200319475328460030956 3200319475328460030956 Yes Department of Traditional Pharmacy, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran