en Pharmacokinetics/Dynamics Pharmacokinetics/Dynamics Review Review <div style="text-align: justify;"><span class="fontstyle0">Zataria multiflora </span><span class="fontstyle2">Boiss L. (</span><span class="fontstyle0">Z. multiflora</span><span class="fontstyle2">) is belonged to the Lamiaceae family, formerly used for culinary and medicinal purposes. Various pharmacological effects of </span><span class="fontstyle0">Z. multiflora </span><span class="fontstyle2">such as bronchodilation, effect on lung inflammation, cold and gynecology disorders have been reported. A literature search was performed in the following databases: Science Direct, PubMed, Scopus and Google Scholar. The keywords including &ldquo;</span><span class="fontstyle0">Zataria multiflora </span><span class="fontstyle2">Boiss.&rdquo;, &ldquo;carvacrol&rdquo;, &ldquo;thymol&rdquo;, &ldquo;linalool&rdquo;, &ldquo;smooth muscle&rdquo; and &ldquo;relaxant effects&rdquo; were searched. The relaxant effects of </span><span class="fontstyle0">Z. multiflora </span><span class="fontstyle2">and its ingredients on different smooth muscles including trachea, vascular, gastrointestinal and urogenital smooth muscle were demonstrated. The relaxant effect of </span><span class="fontstyle0">Z. multiflora </span><span class="fontstyle2">on smooth muscles could be of therapeutic importance, such as bronchodilation in obstructive respiratory disorders, vasodilation in hypertension and reliving digestive or urogenital disorders. The possible mechanisms of the relaxant effect of </span><span class="fontstyle0">Z. multiflora </span><span class="fontstyle2">and its components, mainly carvacrol on smooth muscle such as inhibitory effect on histamine (H</span><span class="fontstyle2" style="font-size:6pt;">1</span><span class="fontstyle2">) and muscarinic receptors, calcium channel blocking effects and stimulatory effect on the beta adrenergic receptor were shown.</span></div> Smooth muscle, Relaxant effect, Zataria multiflora Boiss L, Carvacrol, Thymol, Linalool 213 225 http://ppj.phypha.ir/browse.php?a_code=A-11-828-1&slc_lang=en&sid=1 Mohammad Reza Khazdair M.khazdair@yahoo.com 3200319475328460031273 3200319475328460031273 No Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran Zahra Gholamnezhad 3200319475328460031274 3200319475328460031274 No Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Saeideh Saadat 3200319475328460031275 3200319475328460031275 No Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Mohammad Hossein Boskabady boskabadymh@mums.ac.ir 3200319475328460031276 3200319475328460031276 Yes Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran