Physiology and Pharmacology

en Protective effects of Cinnamomum zeylanicum and Zingiber officinale extract against CCl4-induced acute kidney injury in rats Renal Physiology/Pharmacology Renal Physiology/Pharmacology Experimental research article Experimental research article <div style="text-align: justify;">Introduction: The toxicity induced by toxic substances and medications is one of the principal reasons for acute kidney injury. The purpose of this study was to investigate the effect of Cinnamomum zeylanicum and Zingiber officinale extracts on the kidney of the rats intoxicated with carbon tetrachloride (CCl4). Methods: In this study, thirty-six Wistar rats randomly divided into six groups: I) control, II) cinnamon 25mg/kg + ginger 125mg/kg, III) CCl4, IV) CCl4+ cinnamon 50mg/kg, V) CCl4+ ginger 250mg/kg, VI) CCl4+ cinnamon 25mg/kg and ginger 125mg/kg. Cinnamomum zeylanicum and Zingiber officinale extracts were injected for 14 days. On the 14th day, the rats in the CCl4 and the pretreatment groups were administered with 1mg/kg of CCl4 and olive oil mixture (1:1 v/v). Forty-eight hours after the injection of CCl4, blood samples were taken to conduct subsequent biochemical tests. Also, the kidney removed and histological alterations as well as oxidative markers were investigated. Results: The administration of CCl4 increased the levels of urea, uric acid, creatinine and malondialdehyde; while decreased the levels of serum albumin, total protein, total antioxidant capacity and renal tissue antioxidant enzymes. Pretreatment with Cinnamomum zeylanicum and Zingiber officinale extracts, especially with a combination of them, led to considerable improvement in these values compared to the CCl4 group. Conclusion: The results suggest that hydroalcoholic extracts of Cinnamomum zeylanicum and Zingiber officinale, alone or simultaneously, have protective effects against free radicals produced during CCl4 metabolism.</div> Cinnamomum zeylanicum, Zingiber officinale, Antioxidant, Carbon tetrachloride, Acute kidney injury. 158 167 http://ppj.phypha.ir/browse.php?a_code=A-10-1157-3&slc_lang=en&sid=1 Lotfollah Rezagholizadeh 3200319475328460030944 3200319475328460030944 No Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran Masoud Ojarudi 3200319475328460030945 3200319475328460030945 No Department of Biochemistry, Faculty of Sciences, Payame Noor University, Tehran, Iran Alireza Moradi 3200319475328460030946 3200319475328460030946 No Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Ramin Salimnejad salimnegad67@gmail.com 3200319475328460030947 3200319475328460030947 Yes Department of Anatomical Sciences and Pathology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran Abbas Khonakdar-Tarsi 3200319475328460030948 3200319475328460030948 No Department of Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Somaieh Matin 3200319475328460030949 3200319475328460030949 No Department of Internal Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran Iraj Feizi 3200319475328460030950 3200319475328460030950 No Department of Surgery, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran Alireza Mohammadnia 3200319475328460030951 3200319475328460030951 No Department of Health information technology management, School of medicine, Ardabil University of Medical Sciences, Ardabil, Iran Mohammad Mazani 3200319475328460030952 3200319475328460030952 No Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran