en Blood and Immune System Blood and Immune System Experimental research article Experimental research article <div style="text-align: justify;"><strong><span class="fontstyle0">Introduction: </span></strong><span class="fontstyle2">It has been documented that oxidative stress and inflammation are the main causes of diabetic-induced disorders. Several studies have been reported the antioxidant and antidiabetic effects of prepared asafoetida extracts, from Ferula assafoetida L. species in the Apiaceae family. The aim of the present study was to evaluate the effects of enriched-asafoetida diet (EAD) 0.5% and 2% on plasma level of glucose, hemoglobin A1C (HbA1C), insulin, lipid profile and hepatic enzymes, and vascular endothelial dysfunction induced by type 2 diabetes (T2D). </span><span class="fontstyle0"><strong>Methods:</strong> </span><span class="fontstyle2">Thirty-two male Wistar rats were divided into four groups: 1) control group, 2) diabetic group, 3 and 4) diabetic groups received EAD0.5% and EAD2% for 4 weeks, respectively. T2D was induced by intraperitoneal injection of nicotinamide and streptozotocin. At the end of the experiment, the plasma level of glucose, lipid profile, insulin, oxidative stress, hepatic enzymes and vascular dysfunction were evaluated. </span><span class="fontstyle0"><strong>Results:</strong> </span><span class="fontstyle2">Fasting blood sugar, HbA1C, oxidative stress and hepatic enzymes significantly decreased and plasma level of insulin markedly increased in the EAD0.5 compared to the diabetic group. The plasma lipid profile was improved in the EAD0.5 group. The response of thoracic aorta rings to vasodilators and vasoconstrictor substances was considerably improved in EAD0.5 than in the diabetic group. The EAD2 did not have a significant effect on diabetic induced disorders.<strong> </strong></span><strong><span class="fontstyle0">Conclusion: </span></strong><span class="fontstyle2">The results of the present study suggest that the effects of EAD on biological disorders caused by T2D are dependent on the percentage of asafoetida in the diet.</span></div> Type 2 diabetes, Asafoetida, Hemoglobin A1C, Vascular dysfunction, Lipid profile. 7 19 http://ppj.phypha.ir/browse.php?a_code=A-10-1525-1&slc_lang=en&sid=1 Mansour Esmailidehaj med1354@ssu.ac.ir 3200319475328460030679 3200319475328460030679 Yes Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran Mahboobe Kahtenaroon 3200319475328460030680 3200319475328460030680 No Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran Mohammad Ebrahim Rezvani 3200319475328460030681 3200319475328460030681 No Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran Hossein Azizian 3200319475328460030682 3200319475328460030682 No Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran Alimohammad Ranjbar 3200319475328460030683 3200319475328460030683 No Department of Pharmacognosy, School of Pharmacy Shahid Sadoughi University of Medical Sciences, Yazd, Iran