Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1401
9
1
gregorian
2022
12
1
26
4
online
1
fulltext
en
Bioactive natural products against experimental autoimmune encephalomyelitis: A pharmacokinetics review
Nervous system (others)
Others
Review
Review
<div style="text-align: justify;">Multiple sclerosis (MS) is a central nervous system (CNS) chronic disease in which axons are demyelinated and signal conduction is slowed or blocked. Unfortunately, current drugs that are used to treat MS have limited efficiency and considerable side effects. The use of bioactive natural products for treating neurodegenerative diseases has become of great interest due to their multimodal mechanism of action and potential safety. However, pharmacokinetic parameters such as bioavailability, absorption, metabolic pathways, and elimination routes are essential for evaluating the efficacy and toxicity of herbal medicines and herbal preparations in the clinic. In this review, we have summarized different pharmacokinetic parameters of neuroprotective natural products with anti-experimental autoimmune encephalomyelitis (EAE) effects and recent developments in strategies to improve their bioavailability and effectiveness.</div>
Multiple sclerosis, Demyelination, Natural products, Pharmacokinetics, Experimental autoimmune encephalomyelitis
363
394
http://ppj.phypha.ir/browse.php?a_code=A-11-1533-1&slc_lang=en&sid=1
Leila
Mohtashami
3200319475328460031570
3200319475328460031570
No
Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Abolfazl
Shakeri
3200319475328460031571
3200319475328460031571
No
Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Behjat
Javadi
javadib@mums.ac.ir
3200319475328460031572
3200319475328460031572
Yes
Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran