en Nervous system (others) Others Experimental research article Experimental research article <div style="text-align: justify;"><strong>Introduction:</strong> Diabetic neuropathy is a common complication of diabetes mellitus. It is associated with nerve damage due to oxidative stress and high levels of pro-inflammatory mediators. In the present study, we examined the anti-nociceptive effects of Fullerene nanoparticle, as a potent anti-oxidant, during diabetic neuropathy. <strong>Methods:</strong> Diabetes mellitus induced through injection of streptozotocin (STZ) (40 mg/kg). Four groups were used in the study as follows: the control, control+fullerene, diabetes, and diabetes +fullerene groups. All four groups received sesame oil. Treatment rats received fullerene C60 (1mg/kg/day) for 9 weeks by intra-gastric gavage. Then, cold allodynia, histology, and tumor necrosis factor-&alpha; (TNF- &alpha;) protein expression of the hippocampus were measured 9 weeks after injection of STZ. <strong>Results: </strong>Our data revealed that STZ induces cold allodynia in both hind paws and increases the TNF- &alpha; protein expression in the hippocampus. Furthermore, STZ induces neural degeneration in the hippocampus. Additionally, fullerene C60 significantly attenuated cold allodynia and TNF- &alpha; protein expression. Also, fullerene C60 has neuro-protective effects on hippocampal neurons. However, fullerene C60 did not significantly reduce serum glucose levels in diabetic animals. <strong>Conclusion:</strong> Our data suggest that fullerene C60 likely suppressed pain, and neural loss by inhibitory effects on TNF- &alpha; protein expression in the hippocampus during diabetes.</div> Fullerene C60, Diabetic Neuropathy, TNF-α, Hippocampus 451 458 http://ppj.phypha.ir/browse.php?a_code=A-10-1536-1&slc_lang=en&sid=1 Fariba Namdar 3200319475328460031592 3200319475328460031592 No Pediatric Urology and Regenerative Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran Farideh Bahrami 3200319475328460031593 3200319475328460031593 No Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran Zahra Bahari 3200319475328460031594 3200319475328460031594 No Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran Bahram Ghanbari 3200319475328460031595 3200319475328460031595 No Department of Chemistry, Sharif University of Technology, Tehran, Iran Shima Shahyad 3200319475328460031596 3200319475328460031596 No Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Mohammad Taghi Mohammadi mohammadimohammadt@bmsu.ac.ir 3200319475328460031597 3200319475328460031597 Yes Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran