en Cell, Stem Cell and Cancer Cell, Stem Cell and Cancer Review Review <div style="text-align: justify;"><strong>Introduction:</strong> COVID-19, a novel coronavirus that causes severe acute respiratory syndrome (SARS-CoV-2), is currently regarded as the most serious viral disease. During corona infection, viruses bind to host proteins and employ a variety of cellular pathways for their own purposes. Cell signaling is important for the regulation of cellular function. SARS-CoV-2 infection alters multiple signal transduction pathways that are critical for cell survival. The virus causes a severe and prolonged period of hypercytokinemia with misusing of these signaling cascades. Hyperactivation of the host immune system after infection with SARS-CoV-2 is the main cause of death in COVID-19 patients. Thus, to develop effective therapeutic approaches, it is necessary to first understand the problem and the underlying molecular pathways implicated in host immunological function/dysfunction. A number of intracellular signaling cascades have been implicated in infected cell pathways, including MAPK pathway, NF-&kappa;B pathway, JAK&ndash;STAT signaling pathway, PI3K/AKT/mTOR pathway and TLRI signaling cascades. Here, we have presented the molecular insights on the potential mechanisms involved in immunopathological events of COVID-19.</div> SARS-CoV-2 Infection, Signal transduction pathways, Cytokine storm. 193 205 http://ppj.phypha.ir/browse.php?a_code=A-11-1299-2&slc_lang=en&sid=1 Ali Asghar Peyvandi 3200319475328460029270 3200319475328460029270 No Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Somayeh Niknazar niknazar@sbmu.ac.ir 3200319475328460029271 3200319475328460029271 Yes Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Fatemeh Zare Mehrjerdi 3200319475328460029272 3200319475328460029272 No Neurobiomedical Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Hojjat-Allah Abbaszadeh 3200319475328460029273 3200319475328460029273 No Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Shahrokh Khoshsirat 3200319475328460029274 3200319475328460029274 No Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Maryam Peyvandi 3200319475328460029275 3200319475328460029275 No Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran