en Endocrine Physiology/Pharmacology Endocrine Physiology/Pharmacology Experimental research article Experimental research article <div style="text-align: justify;"><strong>Introduction:</strong> Zingiber officinale (Ginger) is a commonly used plant for food and herbal treatment of different ailments. There is proof of ginger&rsquo;s antioxidative and hypoglycemic activity, but the mechanism of action is yet to be understood, especially in a non-disease model. The present study assessed the effects of the methanolic extract of Zingiber officinale (MEZO) on blood glucose, pancreatic antioxidant levels, and histopathological changes. <strong>Methods: </strong>Fifteen (15) female Wistar rats with an average weight of 147 g were randomly divided into three (3) groups (A-C). Group A was given no treatment and served as the control group. Groups B and C received only oral administration of 400 mg/kg and 800mg/kg of MEZO, respectively. MEZO was administered once a day for 21 days. The animals were euthanized by cervical dislocation for blood collection and retrieval of pancreatic tissue for oxidative stress and histopathological assessment. <strong>Results:</strong> The serum glucose level was significantly decreased in group C compared to the control (P=0.012). There were no significant changes in the levels of Superoxide dismutase (SOD), Glutathione (GSH), and Catalase (CAT) in all the MEZO groups compared to<br /> the control (P>0.05). Pancreatic histology showed signs of acute pancreatitis, with dense aggregates of polymorphonuclear inflammatory cells infiltrating the surrounding stroma. <strong>Conclusion:</strong> A high-dose ginger extract induces hypoglycemia, but a proinflammatory response is elicited in the pancreas at a lower dose. Thus, ginger extracts should be consumed with caution.</div> Ginger, Pancreas, Hypoglycemia, Antioxidants, Inflammation 433 439 http://ppj.phypha.ir/browse.php?a_code=A-10-1391-3&slc_lang=en&sid=1 Izuchukwu Azuka Okafor iza.okafor@unizik.edu.ng 3200319475328460031585 3200319475328460031585 Yes Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, PMB 5001, Nnewi, Nigeria. Uchenna Somtochukwu Okafor okaforu@babcock.edu.ng 3200319475328460031586 3200319475328460031586 No Pan African University of Life and Earth Science Institute (Including Health and Agriculture), PAULESI, University of Ibadan, Ibadan, Nigeria.