Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1401
9
1
gregorian
2022
12
1
26
4
online
1
fulltext
en
The methanolic extract of Zingiber officinale causes hypoglycemia and proinflammatory response in the rat pancreas
Endocrine Physiology/Pharmacology
Endocrine Physiology/Pharmacology
Experimental research article
Experimental research article
<div style="text-align: justify;"><strong>Introduction:</strong> Zingiber officinale (Ginger) is a commonly used plant for food and herbal treatment of different ailments. There is proof of ginger’s antioxidative and hypoglycemic activity, but the mechanism of action is yet to be understood, especially in a non-disease model. The present study assessed the effects of the methanolic extract of Zingiber officinale (MEZO) on blood glucose, pancreatic antioxidant levels, and histopathological changes. <strong>Methods: </strong>Fifteen (15) female Wistar rats with an average weight of 147 g were randomly divided into three (3) groups (A-C). Group A was given no treatment and served as the control group. Groups B and C received only oral administration of 400 mg/kg and 800mg/kg of MEZO, respectively. MEZO was administered once a day for 21 days. The animals were euthanized by cervical dislocation for blood collection and retrieval of pancreatic tissue for oxidative stress and histopathological assessment. <strong>Results:</strong> The serum glucose level was significantly decreased in group C compared to the control (P=0.012). There were no significant changes in the levels of Superoxide dismutase (SOD), Glutathione (GSH), and Catalase (CAT) in all the MEZO groups compared to<br />
the control (P>0.05). Pancreatic histology showed signs of acute pancreatitis, with dense aggregates of polymorphonuclear inflammatory cells infiltrating the surrounding stroma. <strong>Conclusion:</strong> A high-dose ginger extract induces hypoglycemia, but a proinflammatory response is elicited in the pancreas at a lower dose. Thus, ginger extracts should be consumed with caution.</div>
Ginger, Pancreas, Hypoglycemia, Antioxidants, Inflammation
433
439
http://ppj.phypha.ir/browse.php?a_code=A-10-1391-3&slc_lang=en&sid=1
Izuchukwu Azuka
Okafor
iza.okafor@unizik.edu.ng
3200319475328460031585
3200319475328460031585
Yes
Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, PMB 5001, Nnewi, Nigeria.
Uchenna Somtochukwu
Okafor
okaforu@babcock.edu.ng
3200319475328460031586
3200319475328460031586
No
Pan African University of Life and Earth Science Institute (Including Health and Agriculture), PAULESI, University of Ibadan, Ibadan, Nigeria.