en Blood and Immune System Blood and Immune System Experimental research article Experimental research article <p><strong>Introduction:</strong> Two of the most important ion channels in the smooth muscle membrane are L-type and T-type calcium channels. L-type calcium channels are responsible for smooth muscle contraction, while T-type calcium channels are involved in cell membrane depolarization.<br /> <strong>Methods:</strong> In this study, a model consisting of 1200 cells was used to simulate the smooth muscle of the gastric wall. The paper explores the effects of blocking 10%, 50%, 90%, and 100% of L-type and T-type calcium channels on the spatiotemporal wavefront propagation in human gastric wall smooth muscle cells, simulated separately.<br /> <strong>Results:</strong> The results showed that complete blockage had the most significant effect on the slow-wave. Blockage of the L-type calcium channel led to a reduction of -3.4% and -0.8% in the membrane potential during the spike and plateau phases, respectively. The T-type calcium channel reduced the spike and resting membrane potential by -1.8% and -0.9%, respectively. In addition, the L-type calcium channel exhibited a greater impact on reducing muscle contraction compared to the T-type calcium channel. This suggests that higher blockage of calcium channels led to decreased membrane potential during slow-wave phases and reduced muscle contraction, compared to the physiological state.<br /> <strong>Conclusion:</strong> Blocking ion channels in electrophysiological models can potentially help control gastrointestinal tract motility disorders and smooth muscle contraction.</p> Stomach, Smooth Muscle Cell, Slow-wave, Calcium Channel Blockers, Electrophysiology 319 330 http://ppj.phypha.ir/browse.php?a_code=A-10-1659-1&slc_lang=en&sid=1 Hossein Taghadosi h.taghadosi@srbiau.ac.ir 3200319475328460033214 3200319475328460033214 No Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran Farhad Tabatabai Ghomsheh fa.tabatabai@uswr.ac.ir 3200319475328460033215 3200319475328460033215 Yes Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Aydin Farajidavar afarajid@nyit.edu 3200319475328460033216 3200319475328460033216 No Department of Electrical and Computer Engineering, New York Institute of Technology, Old Westbury, New York, USA Faezeh Khazaee faezeh.khazaee@srbiau.ac.ir 3200319475328460033217 3200319475328460033217 No Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran Fatemeh Hoseinpour h.hoseinpour_ot@yahoo.com 3200319475328460033218 3200319475328460033218 No Department of Occupational Therapy, Semnan University of Medical Science, Semnan, Iran