en Neurophysiology/Pharmacology Neurophysiology/Pharmacology Review Review <p>Erythropoietin (EPO) has been considered in several studies as a significant factor in the development of erythroid cells, the inhibition of neuronal cell death, and neurogenesis. Fortunately, a modified version of EPO called carbamylated erythropoietin (CEPO) possesses tissue-protective properties without eliciting erythropoietic effects. CEPO is a derivative of EPO that results in an alpha-amino derivative group with less biological hematopoiesis than EPO. In neurological diseases, CEPO and its carbamylated erythropoietin Fc fusion protein (CEPO-Fc) has been shown to play a better role than EPO. In this study, the effects of EPO and its derivatives on neurological diseases and their role in treatment have been reviewed.</p> EPO, CEPO, Neurological disorders, Alzheimer’s disease 345 356 http://ppj.phypha.ir/browse.php?a_code=A-10-1604-6&slc_lang=en&sid=1 Amirhossein Maghsoudi amirhosein.maghsoudi@yahoo.com 3200319475328460034188 0000000339440284 No Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran Jalal Zaringhalam jzaringhalam@gmail.com 3200319475328460034189 0000000346371686 No Faculty member of Physiology Department, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran Maryam Moosavi mmoosavi2000@gmail.com 3200319475328460034190 000000016943477X No Nanomedicine and Nanobiology Research Centre, Shiraz University of Medical sciences, Shiraz, Iran Akram Eidi eidi@srbiau.ac.ir 3200319475328460034191 0000000266735347 Yes Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran