en Nervous system (others) Others Review Review Pain, an unpleasant feeling resulting from physical or psychological damage, manifests in various diseases such as migraine, fibromyalgia, rheumatoid arthritis, back pain, and neuropathy, disrupting the physiology of the body system. Prolonged pain can detrimentally affect other body tissues, leading to disorders by interfering with hormone secretion. Several studies show that pain can damage the reproductive process. Within the hypothalamus, a population of kisspeptin, neurokinin B, and dynorphin (KNDy) neurons plays an important role in regulating the reproductive axis. This study aims to investigate the effect of pain on hypothalamic neuron activity and its subsequent implications on the reproductive pathway.<br /> <span style="font-size:11pt"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif"><span style="font-size:9.0pt"><span style="line-height:107%"><span style="font-family:"Arial",sans-serif"></span></span></span></span></span></span> Pain, Reproduction, Hypothalamus, Hypothalamic Arcuate nucleus (ARC) 10 17 http://ppj.phypha.ir/browse.php?a_code=A-13-1684-2&slc_lang=en&sid=1 Fariba Mahmoudi f.mahmoudi@uma.ac.ir 3200319475328460034151 0000000160921352 Yes Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran khadijeh Haghighat kh.haghighat@uma.ac.ir 3200319475328460034152 0000000290163086 No Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran