en Nervous system (others) Others Review Review <p><span style="line-height:1.5;"><span style="font-family:Arial;"><span style="font-size:12px;">Circadian rhythm is a biological clock that regulates various physiological and pathological processes in the body. It is believed that any disturbance in circadian rhythm leads to impairment in some physiological systems, such as the endocrine, reproductive, renal, and cardiovascular systems. Various internal and external factors can alter circadian homeostasis and metabolism in a tissue-specific manner, and any disruption in these temporal interactions can result in the development of some chronic disorders. Circadian rhythm plays a crucial role in the pathogenesis of diseases, including cardiovascular disease, neurodegenerative disease, mood disorders, sleep disorders, diabetes mellitus, metabolism disorders, and cancer. This review aims to provide a brief overview of the basic circadian processes and an overview of current and future research directions in circadian rhythm and its related treatments.</span></span></span></p> Circadian rhythm, Physiology, Circadian Clock System, Chronotherapy, Circadian disruption 237 256 http://ppj.phypha.ir/browse.php?a_code=A-10-2252-1&slc_lang=en&sid=1 Shahrzad Sadat Eftekhar Vaghefi 3200319475328460036161 3200319475328460036161 No Pathology and stem cell Research center, Kerman University of Medical, Sciences, Kerman, Iran Reza Malekpour Afshar 3200319475328460036162 3200319475328460036162 No Pathology and stem cell Research center, Kerman University of Medical, Sciences, Kerman, Iran Fatemeh Shahsavari 3200319475328460036163 3200319475328460036163 No Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran Fatemeh Mousavi 3200319475328460036164 3200319475328460036164 No Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Seyed Hossein Eftekhar Vaghefi 3200319475328460036165 3200319475328460036165 No Pathology and stem cell Research center, Kerman University of Medical, Sciences, Kerman, Iran Seyyed Jafar Nosratabadi 3200319475328460036166 3200319475328460036166 No Department of Basic Sciences, Faculty of Medicine, Kerman Branch, Islamic Azad University, Kerman, Iran Mohammad Khaksari 3200319475328460036167 3200319475328460036167 No Department of Physiology and Pharmacology, Kerman University of Medical Sciences, Kerman, Iran Zahra Soltani 3200319475328460036168 3200319475328460036168 No Department of Physiology and Pharmacology, Kerman University of Medical Sciences, Kerman, Iran Gholamreza Asadikaram 3200319475328460036169 3200319475328460036169 No Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Manzoomeh Shamsi Meymandi 3200319475328460036170 3200319475328460036170 No Pathology and stem cell Research center, Kerman University of Medical, Sciences, Kerman, Iran Alireza Raji Amir Hasani 3200319475328460036171 3200319475328460036171 No Department of Physiology and Pharmacology, Kerman University of Medical Sciences, Kerman, Iran Mona Saheli 3200319475328460036172 3200319475328460036172 No Department of Anatomical Sciences, Kerman University of Medical Sciences, Kerman, Iran Masoumeh Baghalishahi 3200319475328460036173 3200319475328460036173 No Department of Anatomical Sciences, Kerman University of Medical Sciences, Kerman, Iran Maryam Fekri Soofi Abadi 3200319475328460036174 3200319475328460036174 No Pathology and stem cell Research center, Kerman University of Medical, Sciences, Kerman, Iran Mahnaz Mohammadizadeh 3200319475328460036175 3200319475328460036175 No Pathology and stem cell Research center, Kerman University of Medical, Sciences, Kerman, Iran Shahriar Dabiri dabiri12@yahoo.com 3200319475328460036176 0000000259223976 Yes Pathology and Stem Cell Research Center, Department of Pathology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran